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Dose of aspirin to prevent preterm preeclampsia in women with moderate or high-risk factors: A systematic review and meta-analysis

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  • Rachel Van Doorn
  • Narmin Mukhtarova
  • Ian P Flyke
  • Michael Lasarev
  • KyungMann Kim
  • Charles H Hennekens
  • Kara K Hoppe

Abstract

Objective: To evaluate the effect of aspirin dose on the incidence of all gestational age preeclampsia and preterm preeclampsia. Data sources: Electronic databases (Cochrane, PubMed, Scopus, ClinicalTrials.gov and the Web of Science) were searched for articles published between January 1985 and March 2019 with no language restrictions. Methods: We followed the PRIMSA guidelines and utilized Covidence software. Articles were screened by 2 independent reviewers, with discrepancies settled by an independent 3rd party. Study selection criteria were randomized trials comparing aspirin for prevention of all gestational age and preterm preeclampsia to placebo or no antiplatelet treatment in women aged 15–55 years with moderate or high-risk factors according to the list of risk factors from American College of Obstetricians and Gynecologists and United States Preventive Services Task Force guidelines. The quality of trials was assessed using the Cochrane risk of bias tool. The data were pooled using a random-effects meta-analysis comparing aspirin at doses of

Suggested Citation

  • Rachel Van Doorn & Narmin Mukhtarova & Ian P Flyke & Michael Lasarev & KyungMann Kim & Charles H Hennekens & Kara K Hoppe, 2021. "Dose of aspirin to prevent preterm preeclampsia in women with moderate or high-risk factors: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.
    • Handle: RePEc:plo:pone00:0247782
    DOI: 10.1371/journal.pone.0247782
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