IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0240995.html
   My bibliography  Save this article

Risk factors for surgical site infections using a data-driven approach

Author

Listed:
  • J M van Niekerk
  • M C Vos
  • A Stein
  • L M A Braakman-Jansen
  • A F Voor in ‘t holt
  • J E W C van Gemert-Pijnen

Abstract

Objective: The objective of this study was to identify risk factors for surgical site infection from digestive, thoracic and orthopaedic system surgeries using clinical and data-driven cut-off values. A second objective was to compare the identified risk factors in this study to risk factors identified in literature. Summary background data: Retrospective data of 3 250 surgical procedures performed in large tertiary care hospital in The Netherlands during January 2013 to June 2014 were used. Methods: Potential risk factors were identified using a literature scan and univariate analysis. A multivariate forward-step logistic regression model was used to identify risk factors. Standard medical cut-off values were compared with cut-offs determined from the data. Results: For digestive, orthopaedic and thoracic system surgical procedures, the risk factors identified were preoperative temperature of ≥38°C and antibiotics used at the time of surgery. C-reactive protein and the duration of the surgery were identified as a risk factors for digestive surgical procedures. Being an adult (age ≥18) was identified as a protective effect for thoracic surgical procedures. Data-driven cut-off values were identified for temperature, age and CRP which can explain the SSI outcome up to 19.5% better than generic cut-off values. Conclusions: This study identified risk factors for digestive, orthopaedic and thoracic system surgical procedures and illustrated how data-driven cut-offs can add value in the process. Future studies should investigate if data-driven cut-offs can add value to explain the outcome being modelled and not solely rely on standard medical cut-off values to identify risk factors.

Suggested Citation

  • J M van Niekerk & M C Vos & A Stein & L M A Braakman-Jansen & A F Voor in ‘t holt & J E W C van Gemert-Pijnen, 2020. "Risk factors for surgical site infections using a data-driven approach," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-14, October.
    • Handle: RePEc:plo:pone00:0240995
    DOI: 10.1371/journal.pone.0240995
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0240995
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0240995&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0240995?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. van Buuren, Stef & Groothuis-Oudshoorn, Karin, 2011. "mice: Multivariate Imputation by Chained Equations in R," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 45(i03).
    2. Nicolas Fiorini & Kathi Canese & Grisha Starchenko & Evgeny Kireev & Won Kim & Vadim Miller & Maxim Osipov & Michael Kholodov & Rafis Ismagilov & Sunil Mohan & James Ostell & Zhiyong Lu, 2018. "Best Match: New relevance search for PubMed," PLOS Biology, Public Library of Science, vol. 16(8), pages 1-12, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Noémi Kreif & Richard Grieve & Iván Díaz & David Harrison, 2015. "Evaluation of the Effect of a Continuous Treatment: A Machine Learning Approach with an Application to Treatment for Traumatic Brain Injury," Health Economics, John Wiley & Sons, Ltd., vol. 24(9), pages 1213-1228, September.
    2. Abhilash Bandam & Eedris Busari & Chloi Syranidou & Jochen Linssen & Detlef Stolten, 2022. "Classification of Building Types in Germany: A Data-Driven Modeling Approach," Data, MDPI, vol. 7(4), pages 1-23, April.
    3. Boonstra Philip S. & Little Roderick J.A. & West Brady T. & Andridge Rebecca R. & Alvarado-Leiton Fernanda, 2021. "A Simulation Study of Diagnostics for Selection Bias," Journal of Official Statistics, Sciendo, vol. 37(3), pages 751-769, September.
    4. Christopher J Greenwood & George J Youssef & Primrose Letcher & Jacqui A Macdonald & Lauryn J Hagg & Ann Sanson & Jenn Mcintosh & Delyse M Hutchinson & John W Toumbourou & Matthew Fuller-Tyszkiewicz &, 2020. "A comparison of penalised regression methods for informing the selection of predictive markers," PLOS ONE, Public Library of Science, vol. 15(11), pages 1-14, November.
    5. Liangyuan Hu & Lihua Li, 2022. "Using Tree-Based Machine Learning for Health Studies: Literature Review and Case Series," IJERPH, MDPI, vol. 19(23), pages 1-13, December.
    6. Norah Alyabs & Sy Han Chiou, 2022. "The Missing Indicator Approach for Accelerated Failure Time Model with Covariates Subject to Limits of Detection," Stats, MDPI, vol. 5(2), pages 1-13, May.
    7. Feldkircher, Martin, 2014. "The determinants of vulnerability to the global financial crisis 2008 to 2009: Credit growth and other sources of risk," Journal of International Money and Finance, Elsevier, vol. 43(C), pages 19-49.
    8. Eunsil Seok & Akhgar Ghassabian & Yuyan Wang & Mengling Liu, 2024. "Statistical Methods for Modeling Exposure Variables Subject to Limit of Detection," Statistics in Biosciences, Springer;International Chinese Statistical Association, vol. 16(2), pages 435-458, July.
    9. Ida Kubiszewski & Kenneth Mulder & Diane Jarvis & Robert Costanza, 2022. "Toward better measurement of sustainable development and wellbeing: A small number of SDG indicators reliably predict life satisfaction," Sustainable Development, John Wiley & Sons, Ltd., vol. 30(1), pages 139-148, February.
    10. Georges Steffgen & Philipp E. Sischka & Martha Fernandez de Henestrosa, 2020. "The Quality of Work Index and the Quality of Employment Index: A Multidimensional Approach of Job Quality and Its Links to Well-Being at Work," IJERPH, MDPI, vol. 17(21), pages 1-31, October.
    11. Christopher Kath & Florian Ziel, 2018. "The value of forecasts: Quantifying the economic gains of accurate quarter-hourly electricity price forecasts," Papers 1811.08604, arXiv.org.
    12. Esef Hakan Toytok & Sungur Gürel, 2019. "Does Project Children’s University Increase Academic Self-Efficacy in 6th Graders? A Weak Experimental Design," Sustainability, MDPI, vol. 11(3), pages 1-12, February.
    13. Joost R. Ginkel, 2020. "Standardized Regression Coefficients and Newly Proposed Estimators for $${R}^{{2}}$$R2 in Multiply Imputed Data," Psychometrika, Springer;The Psychometric Society, vol. 85(1), pages 185-205, March.
    14. Lara Jehi & Xinge Ji & Alex Milinovich & Serpil Erzurum & Amy Merlino & Steve Gordon & James B Young & Michael W Kattan, 2020. "Development and validation of a model for individualized prediction of hospitalization risk in 4,536 patients with COVID-19," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-15, August.
    15. Matthew Carli & Mary H. Ward & Catherine Metayer & David C. Wheeler, 2022. "Imputation of Below Detection Limit Missing Data in Chemical Mixture Analysis with Bayesian Group Index Regression," IJERPH, MDPI, vol. 19(3), pages 1-17, January.
    16. Gerko Vink & Laurence E. Frank & Jeroen Pannekoek & Stef Buuren, 2014. "Predictive mean matching imputation of semicontinuous variables," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 68(1), pages 61-90, February.
    17. Tsai, Tsung-Han, 2016. "A Bayesian Approach to Dynamic Panel Models with Endogenous Rarely Changing Variables," Political Science Research and Methods, Cambridge University Press, vol. 4(3), pages 595-620, September.
    18. Henry Webel & Lili Niu & Annelaura Bach Nielsen & Marie Locard-Paulet & Matthias Mann & Lars Juhl Jensen & Simon Rasmussen, 2024. "Imputation of label-free quantitative mass spectrometry-based proteomics data using self-supervised deep learning," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    19. Debra Javeline & Tracy Kijewski-Correa & Angela Chesler, 2019. "Does it matter if you “believe” in climate change? Not for coastal home vulnerability," Climatic Change, Springer, vol. 155(4), pages 511-532, August.
    20. Simon Grund & Oliver Lüdtke & Alexander Robitzsch, 2018. "Multiple Imputation of Missing Data at Level 2: A Comparison of Fully Conditional and Joint Modeling in Multilevel Designs," Journal of Educational and Behavioral Statistics, , vol. 43(3), pages 316-353, June.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0240995. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.