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The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population

Author

Listed:
  • Beáta Soltész
  • Péter Pikó
  • János Sándor
  • Zsigmond Kósa
  • Róza Ádány
  • Szilvia Fiatal

Abstract

Estimating the prevalence of cardiovascular diseases (CVDs) and risk factors among the Roma population, the largest minority in Europe, and investigating the role of genetic or environmental/behavioral risk factors in CVD development are important issues in countries where they are significant minority. This study was designed to estimate the genetic susceptibility of the Hungarian Roma (HR) population to essential hypertension (EH) and compare it to that of the general (HG) population. Twenty EH associated SNPs (in AGT, FMO3, MTHFR-NPPB, NPPA, NPPA-AS1, AGTR1, ADD1, NPR3-C5orf23, NOS3, CACNB2, PLCE1, ATP2B1, GNB3, CYP1A1-ULK3, UMOD and GNAS-EDN3) were genotyped using DNA samples obtained from HR (N = 1176) and HG population (N = 1178) subjects assembled by cross-sectional studies. Allele frequencies and genetic risk scores (unweighted and weighted genetic risk scores (GRS and wGRS, respectively) were calculated for the study groups and compared to examine the joint effects of the SNPs. The susceptibility alleles were more frequent in the HG population, and both GRS and wGRS were found to be higher in the HG population than in the HR population (GRS: 18.98 ± 3.05 vs. 18.25 ± 2.97, p

Suggested Citation

  • Beáta Soltész & Péter Pikó & János Sándor & Zsigmond Kósa & Róza Ádány & Szilvia Fiatal, 2020. "The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0234547
    DOI: 10.1371/journal.pone.0234547
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    1. Sandosh Padmanabhan & Olle Melander & Toby Johnson & Anna Maria Di Blasio & Wai K Lee & Davide Gentilini & Claire E Hastie & Cristina Menni & Maria Cristina Monti & Christian Delles & Stewart Laing & , 2010. "Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension," PLOS Genetics, Public Library of Science, vol. 6(10), pages 1-11, October.
    2. Zeljko, Hrvojka Marija & Škarić-Jurić, Tatjana & Narančić, Nina Smolej & Barešić, Ana & Tomas, Željka & Petranović, Matea Zajc & Miličić, Jasna & Salihović, Marijana Peričić & Janićijević, Branka, 2013. "Age trends in prevalence of cardiovascular risk factors in Roma minority population of Croatia," Economics & Human Biology, Elsevier, vol. 11(3), pages 326-336.
    3. Kuo Liu & Jielin Liu & Yan Huang & Ya Liu & Yuqing Lou & Zuoguang Wang & Hong Zhang & Shan Yan & Zhizhong Li & Shaojun Wen, 2010. "Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-9, September.
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