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Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls

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Listed:
  • Kuo Liu
  • Jielin Liu
  • Yan Huang
  • Ya Liu
  • Yuqing Lou
  • Zuoguang Wang
  • Hong Zhang
  • Shan Yan
  • Zhizhong Li
  • Shaojun Wen

Abstract

Background: No clear consensus has been reached on the alpha-adducin polymorphism (Gly460Trp) and essential hypertension risk. We performed a meta-analysis in an effort to systematically summarize the possible association. Methodology/Principal Findings: Studies were identified by searching MEDLINE and EMBASE databases complemented with perusal of bibliographies of retrieved articles and correspondence with original authors. The fixed-effects model and the random-effects model were applied for dichotomous outcomes to combine the results of the individual studies. We selected 22 studies that met the inclusion criteria including a total of 14303 hypertensive patients and 15961 normotensive controls. Overall, the 460Trp allele showed no statistically significant association with hypertension risk compared to Gly460 allele (P = 0.69, OR = 1.02, 95% CI 0.94–1.10, Pheterogeneity

Suggested Citation

  • Kuo Liu & Jielin Liu & Yan Huang & Ya Liu & Yuqing Lou & Zuoguang Wang & Hong Zhang & Shan Yan & Zhizhong Li & Shaojun Wen, 2010. "Alpha-Adducin Gly460Trp Polymorphism and Hypertension Risk: A Meta-Analysis of 22 Studies Including 14303 Cases and 15961 Controls," PLOS ONE, Public Library of Science, vol. 5(9), pages 1-9, September.
  • Handle: RePEc:plo:pone00:0013057
    DOI: 10.1371/journal.pone.0013057
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    Cited by:

    1. Beáta Soltész & Péter Pikó & János Sándor & Zsigmond Kósa & Róza Ádány & Szilvia Fiatal, 2020. "The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    2. Yan-yan Li, 2012. "α-Adducin Gly460Trp Gene Mutation and Essential Hypertension in a Chinese Population: A Meta-Analysis including 10960 Subjects," PLOS ONE, Public Library of Science, vol. 7(1), pages 1-12, January.

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