IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0237364.html
   My bibliography  Save this article

Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study

Author

Listed:
  • Cornelia Then
  • Barbara Thorand
  • Holger L Then
  • Christa Meisinger
  • Margit Heier
  • Annette Peters
  • Wolfgang Koenig
  • Wolfgang Rathmann
  • Martin Bidlingmaier
  • Andreas Lechner
  • Martin Reincke
  • Jürgen E Scherberich
  • Jochen Seissler

Abstract

Objectives: Uromodulin has been associated with arterial hypertension in genome-wide association studies, but data from clinical and preclinical studies are inconsistent. We here analyzed the association of serum uromodulin (sUmod) with arterial hypertension and vasoactive hormones in a population-based study. Methods: In 1108 participants of the KORA F4 study aged 62–81 years, sUmod was measured and the association of sUmod with arterial hypertension was assessed using logistic regression models. The associations of sUmod with renin and aldosterone and with the vasoconstrictive prohormone C-terminal pro-endothelin-1 (CT-proET-1) were analyzed in 1079 participants and in 618 participants, respectively, using linear regression models. Results: After multivariable adjustment including sex, age, eGFR, BMI, fasting glucose, current smoking, previous stroke and myocardial infarction, sUmod was inversely associated with arterial hypertension (OR 0.78; 95% CI 0.68–0.91; p = 0.001). SUmod was not significantly associated with renin and aldosterone after adjustment for sex, age and eGFR. However, sUmod was inversely associated with CT-proET-1 (β -0.19 ± 0.04; p

Suggested Citation

  • Cornelia Then & Barbara Thorand & Holger L Then & Christa Meisinger & Margit Heier & Annette Peters & Wolfgang Koenig & Wolfgang Rathmann & Martin Bidlingmaier & Andreas Lechner & Martin Reincke & Jür, 2020. "Serum uromodulin is inversely associated with arterial hypertension and the vasoconstrictive prohormone CT-proET-1 in the population-based KORA F4 study," PLOS ONE, Public Library of Science, vol. 15(8), pages 1-12, August.
  • Handle: RePEc:plo:pone00:0237364
    DOI: 10.1371/journal.pone.0237364
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0237364
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0237364&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0237364?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Sandosh Padmanabhan & Olle Melander & Toby Johnson & Anna Maria Di Blasio & Wai K Lee & Davide Gentilini & Claire E Hastie & Cristina Menni & Maria Cristina Monti & Christian Delles & Stewart Laing & , 2010. "Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension," PLOS Genetics, Public Library of Science, vol. 6(10), pages 1-11, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Beáta Soltész & Péter Pikó & János Sándor & Zsigmond Kósa & Róza Ádány & Szilvia Fiatal, 2020. "The genetic risk for hypertension is lower among the Hungarian Roma population compared to the general population," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    2. Jingjing Zhou & Yuqing Chen & Ying Liu & Sufang Shi & Suxia Wang & Xueying Li & Hong Zhang & Haiyan Wang, 2013. "Urinary Uromodulin Excretion Predicts Progression of Chronic Kidney Disease Resulting from IgA Nephropathy," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-6, August.
    3. Frank Konietschke & Ondrej Libiger & Ludwig A Hothorn, 2012. "Nonparametric Evaluation of Quantitative Traits in Population-Based Association Studies when the Genetic Model is Unknown," PLOS ONE, Public Library of Science, vol. 7(2), pages 1-10, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0237364. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.