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Intermittent epidural bolus versus continuous epidural infusions for labor analgesia: A meta-analysis of randomized controlled trials

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  • Xian Liu
  • Huan Zhang
  • Haijing Zhang
  • Mengzhuo Guo
  • Yuanchao Gao
  • Chunyan Du

Abstract

There are inconsistent results regarding the efficacy and safety of intermittent epidural bolus (IPB) versus continuous epidural infusions (CPI) for labor analgesia. This study used a meta-analytic approach to assess the safety and treatment efficacy of IPB versus CPI for labor analgesia based on randomized controlled trials (RCTs). Four electronic databases were used to identify eligible RCTs. Pooled effect estimates at 95% confidence intervals (CIs) were calculated using a random-effects model. Twenty-two RCTs with 2,573 parturients were selected for final analysis. The findings revealed no significant differences between IPB and CPI for the incidences of cesarean and instrumental delivery. IPB was shown to be associated with shorter total duration of labor [weighted mean difference (WMD): −21.46; 95% CI: −25.07 to −17.85; P

Suggested Citation

  • Xian Liu & Huan Zhang & Haijing Zhang & Mengzhuo Guo & Yuanchao Gao & Chunyan Du, 2020. "Intermittent epidural bolus versus continuous epidural infusions for labor analgesia: A meta-analysis of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 15(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0234353
    DOI: 10.1371/journal.pone.0234353
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    References listed on IDEAS

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    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    Cited by:

    1. I-Shiang Tzeng & Ming-Chang Kao & Po-Ting Pan & Chu-Ting Chen & Han-Yu Lin & Po-Chun Hsieh & Chan-Yen Kuo & Tsung-Han Hsieh & Woon-Man Kung & Chu-Hsuan Cheng & Kuo-Hu Chen, 2020. "A Meta-Analysis of Comparing Intermittent Epidural Boluses and Continuous Epidural Infusion for Labor Analgesia," IJERPH, MDPI, vol. 17(19), pages 1-16, September.

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