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The long-term effects of a family based economic empowerment intervention (Suubi+Adherence) on suppression of HIV viral loads among adolescents living with HIV in southern Uganda: Findings from 5-year cluster randomized trial

Author

Listed:
  • Fred M Ssewamala
  • Darejan Dvalishvili
  • Claude A Mellins
  • Elvin H Geng
  • Fredderick Makumbi
  • Torsten B Neilands
  • Mary McKay
  • Christopher Damulira
  • Proscovia Nabunya
  • Ozge Sensoy Bahar
  • Gertrude Nakigozi
  • Godfrey Kigozi
  • William Byansi
  • Miriam Mukasa
  • Flavia Namuwonge

Abstract

Background: The rapid scale-up of HIV therapy across Africa has failed to adequately engage adolescents living with HIV (ALWHIV). Retention and viral suppression for this group (ALWHIV) is 50% lower than for adults. Indeed, on the African continent, HIV remains the single leading cause of mortality among adolescents. Strategies tailored to the unqiue developmental and social vulnerabilities of this group are urgently needed to enhance successful treatment. Methods: We carried out a five-year longitudinal cluster randomized trial (ClinicalTrials.gov ID: NCT01790373) with adolescents living with HIV (ALWHIV) ages 10 to 16 years clustered at health care clinics to test the effect of a family economic empowerment (EE) intervention on viral suppression in five districuts in Uganda. In total, 39 accredited health care clinics from study districts with existing procedures tailored to adolescent adherence were eligible to participate in the trial. We used data from 288 youth with detectable HIV viral loads (VL) at baseline (158 –intervention group from 20 clinics, 130 –non-intervention group from 19 clinics). The primary end point was undetectable plasma HIV RNA levels, defined as

Suggested Citation

  • Fred M Ssewamala & Darejan Dvalishvili & Claude A Mellins & Elvin H Geng & Fredderick Makumbi & Torsten B Neilands & Mary McKay & Christopher Damulira & Proscovia Nabunya & Ozge Sensoy Bahar & Gertrud, 2020. "The long-term effects of a family based economic empowerment intervention (Suubi+Adherence) on suppression of HIV viral loads among adolescents living with HIV in southern Uganda: Findings from 5-year," PLOS ONE, Public Library of Science, vol. 15(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0228370
    DOI: 10.1371/journal.pone.0228370
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    References listed on IDEAS

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    1. Peter Piot & Robert Greener & Sarah Russell, 2007. "Squaring the Circle: AIDS, Poverty, and Human Development," PLOS Medicine, Public Library of Science, vol. 4(10), pages 1-5, October.
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    1. Darejan Dvalishvili & Fred. M. Ssewamala & Proscovia Nabunya & Ozge Sensoy Bahar & Samuel Kizito & Flavia Namuwonge & Phionah Namatovu, 2022. "Impact of Family-Based Economic Empowerment Intervention, Suubi+Adherence (2012–2018) on Multidimensional Poverty for Adolescents Living with HIV (ALWHIV) in Uganda," IJERPH, MDPI, vol. 19(21), pages 1-17, November.

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