IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0225650.html
   My bibliography  Save this article

Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD

Author

Listed:
  • Nicholas John Dean
  • Christopher Pastras
  • Daniel Brown
  • Aaron Camp

Abstract

Despite considerable research, it remains controversial as to whether viral-infections are associated with Meniere’s Disease (MD), a clinically heterogeneous set of chronic inner-ear disorders strongly associated with endolymphatic hydrops. Here, we investigated whether viral-infections are associated with MD through a systematic review and meta-analysis of observational clinical studies using molecular-diagnostics. Eligible for inclusion were case-controlled studies which ascertained molecular-determinants of past or present viral-infection through either viral nucleic acids or host serological marker in MD cases and non-MD controls. Across online databases and grey literature, we identified 210 potentially relevant articles in the English language, from which a total of 14 articles fully satisfied our eligibility criteria such that meta-groups of 611 MD-cases and 373 controls resulted. The aggregate quality of the modest-sized (14 studies) body of evidence was limited and varied considerably with regards to participant selection, matching, and ascertainment(s) and determinant(s) of viral-infection. Most data identified concerned the human cytomegalovirus (CMV), and meta-analysis of eligible studies revealed that evidence of CMV-infection was associated approximately three-fold with MD compared to controls, however the timing of the infections was indeterminate as the pooled analyses combined antiviral serological markers with viral nucleic acid markers. No association was found for any of HSV-1, -2, VZV, or EBV. Associative analyses of any viral species not aforementioned were precluded by limited data, and thus potential associations between other viral species and MD, especially other than Herpesviridae, are yet to be characterised. Overall, we have found a small association between CMV-infection and MD, however it is to be determined for what sub-groups of MD this finding may be relevant, and ideally the reported association remains would be reproduced by a greater volume of higher quality evidence.

Suggested Citation

  • Nicholas John Dean & Christopher Pastras & Daniel Brown & Aaron Camp, 2019. "Are viral-infections associated with Ménière’s Disease? A systematic review and meta-analysis of molecular-markers of viral-infection in case-controlled observational studies of MD," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-23, November.
  • Handle: RePEc:plo:pone00:0225650
    DOI: 10.1371/journal.pone.0225650
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0225650
    Download Restriction: no

    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0225650&type=printable
    Download Restriction: no

    File URL: https://libkey.io/10.1371/journal.pone.0225650?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Viechtbauer, Wolfgang, 2010. "Conducting Meta-Analyses in R with the metafor Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i03).
    2. Sue Duval & Richard Tweedie, 2000. "Trim and Fill: A Simple Funnel-Plot–Based Method of Testing and Adjusting for Publication Bias in Meta-Analysis," Biometrics, The International Biometric Society, vol. 56(2), pages 455-463, June.
    3. Olaf M Dekkers & Jan P Vandenbroucke & Myriam Cevallos & Andrew G Renehan & Douglas G Altman & Matthias Egger, 2019. "COSMOS-E: Guidance on conducting systematic reviews and meta-analyses of observational studies of etiology," PLOS Medicine, Public Library of Science, vol. 16(2), pages 1-24, February.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Bart Verkuil & Serpil Atasayi & Marc L Molendijk, 2015. "Workplace Bullying and Mental Health: A Meta-Analysis on Cross-Sectional and Longitudinal Data," PLOS ONE, Public Library of Science, vol. 10(8), pages 1-16, August.
    2. Molo, Fabio & Pawel, Samuel & Fraga González, Gorka, 2024. "A Robustness Reproduction of "A Systematic Review and Meta-Analysis of 90 Cohort Studies of Social Isolation, Loneliness and Mortality"," I4R Discussion Paper Series 169, The Institute for Replication (I4R).
    3. Augusteijn, Hilde Elisabeth Maria & van Aert, Robbie Cornelis Maria & van Assen, Marcel A. L. M., 2021. "Posterior Probabilities of Effect Sizes and Heterogeneity in Meta-Analysis: An Intuitive Approach of Dealing with Publication Bias," OSF Preprints avkgj, Center for Open Science.
    4. Georgiou, George K. & Guo, Kan & Naveenkumar, Nithya & Vieira, Ana Paula Alves & Das, J.P., 2020. "PASS theory of intelligence and academic achievement: A meta-analytic review," Intelligence, Elsevier, vol. 79(C).
    5. Geller, Susann & Wilhelm, Oliver & Wacker, Jan & Hamm, Alfons & Hildebrandt, Andrea, 2017. "Associations of the COMT Val158Met polymorphism with working memory and intelligence – A review and meta-analysis," Intelligence, Elsevier, vol. 65(C), pages 75-92.
    6. Christopher Winchester & Kelsey E. Medeiros, 2023. "In Bounds but Out of the Box: A Meta-Analysis Clarifying the Effect of Ethicality on Creativity," Journal of Business Ethics, Springer, vol. 183(3), pages 713-743, March.
    7. Nian-Feng Wan & Liwan Fu & Matteo Dainese & Yue-Qing Hu & Lars Pødenphant Kiær & Forest Isbell & Christoph Scherber, 2022. "Plant genetic diversity affects multiple trophic levels and trophic interactions," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    8. Franco Curadelli & Marcelo Alberto & Ernesto Martín Uliarte & Mariana Combina & Iván Funes-Pinter, 2023. "Meta-Analysis of Yields of Crops Fertilized with Compost Tea and Anaerobic Digestate," Sustainability, MDPI, vol. 15(2), pages 1-23, January.
    9. Kim, Yeolib & Kim, Seung Hyun & Peterson, Robert A. & Choi, Jeonghye, 2023. "Privacy concern and its consequences: A meta-analysis," Technological Forecasting and Social Change, Elsevier, vol. 196(C).
    10. Smith, Stephanie R. & Kroon, Jeroen & Schwarzer, Ralf & Hamilton, Kyra, 2020. "Parental social-cognitive correlates of preschoolers’ oral hygiene behavior: A systematic review and meta-analysis," Social Science & Medicine, Elsevier, vol. 264(C).
    11. K. Praveen Parboteeah & Matthias Weiss & Martin Hoegl, 2024. "Ethical Climates Across National Contexts: A Meta-Analytical Investigation," Journal of Business Ethics, Springer, vol. 189(3), pages 573-590, January.
    12. Woodley of Menie, Michael A. & Peñaherrera-Aguirre, Mateo & Sarraf, Matthew A., 2022. "Signs of a Flynn effect in rodents? Secular differentiation of the manifold of general cognitive ability in laboratory mice (Mus musculus) and Norwegian rats (Rattus norvegicus) over a century—Results," Intelligence, Elsevier, vol. 95(C).
    13. Wenke, Kathrin & Zapkau, Florian B. & Schwens, Christian, 2021. "Too small to do it all? A meta-analysis on the relative relationships of exploration, exploitation, and ambidexterity with SME performance," Journal of Business Research, Elsevier, vol. 132(C), pages 653-665.
    14. Stav Fainshmidt & Amir Pezeshkan & M. Lance Frazier & Anil Nair & Edward Markowski, 2016. "Dynamic Capabilities and Organizational Performance: A Meta-Analytic Evaluation and Extension," Journal of Management Studies, Wiley Blackwell, vol. 53(8), pages 1348-1380, December.
    15. Jaskiewicz, Peter & Block, Joern & Wagner, Dominik & Carney, Michael & Hansen, Christopher, 2021. "How do cross-country differences in institutional trust and trust in family explain the mixed performance effects of family management? A meta-analysis," Journal of World Business, Elsevier, vol. 56(5).
    16. Anouk Decuypere & Wilmar Schaufeli, 2021. "Exploring the Leadership–Engagement Nexus: A Moderated Meta-Analysis and Review of Explaining Mechanisms," IJERPH, MDPI, vol. 18(16), pages 1-34, August.
    17. Haiko Schurz & Michelle Daya & Marlo Möller & Eileen G Hoal & Muneeb Salie, 2015. "TLR1, 2, 4, 6 and 9 Variants Associated with Tuberculosis Susceptibility: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-24, October.
    18. Lütjens, Henk & Eisenbeiss, Maik & Fiedler, Maximilian & Bijmolt, Tammo, 2022. "Determinants of consumers’ attitudes towards digital advertising – A meta-analytic comparison across time and touchpoints," Journal of Business Research, Elsevier, vol. 153(C), pages 445-466.
    19. Sala, Giovanni & Aksayli, N. Deniz & Tatlidil, K. Semir & Gondo, Yasuyuki & Gobet, Fernand, 2019. "Working memory training does not enhance older adults' cognitive skills: A comprehensive meta-analysis," Intelligence, Elsevier, vol. 77(C).
    20. Kadykalo, Andrew N. & Findlay, C. Scott, 2016. "The flow regulation services of wetlands," Ecosystem Services, Elsevier, vol. 20(C), pages 91-103.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0225650. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.