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Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

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  • Xian Zhang
  • Yi Lin
  • Xiaoning Xie
  • Meiya Shen
  • Guoping Huang
  • Yunmei Yang

Abstract

Introduction: Previous studies regarding the relationship between acne and prostate cancer risk have reported inconsistent results. We performed the present meta-analysis of observational studies to summarize the evidence on this association. Methods: A comprehensive literature search up to March 2018 was performed in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with a random effects model. The Q statistic and the I2 index were used to evaluate the heterogeneity across the studies. Results: Eight studies were ultimately included in this meta-analysis. In the overall analysis, no significant association was found between acne and prostate cancer risk (OR = 1.08, 95% CI 0.93–1.25). A significant heterogeneity was observed across studies (P = 0.006, I2 = 64.5%). In the subgroup analysis by study design, a significant association was observed in the cohort studies (OR = 1.51, 95% CI 1.19–1.93) but not in the case-control studies (OR = 0.98, 95% CI 0.86–1.12). Conclusions: In summary, this meta-analysis did not find an association between acne in adolescence and prostate cancer risk. However, because there was some heterogeneity in the overall analysis and a significant association was observed in the meta-analysis of the cohort studies, further well-designed large prospective studies are warranted to confirm our results.

Suggested Citation

  • Xian Zhang & Yi Lin & Xiaoning Xie & Meiya Shen & Guoping Huang & Yunmei Yang, 2018. "Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-10, November.
    • Handle: RePEc:plo:pone00:0206249
    DOI: 10.1371/journal.pone.0206249
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    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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