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The cortical structure of functional networks associated with age-related cognitive abilities in older adults

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  • Michael B Kranz
  • Michelle W Voss
  • Gillian E Cooke
  • Sarah E Banducci
  • Agnieszka Z Burzynska
  • Arthur F Kramer

Abstract

Age and cortical structure are both associated with cognition, but characterizing this relationship remains a challenge. A popular approach is to use functional network organization of the cortex as an organizing principle for post-hoc interpretations of structural results. In the current study, we introduce two complimentary approaches to structural analyses that are guided by a-priori functional network maps. Specifically, we systematically investigated the relationship of cortical structure (thickness and surface area) of distinct functional networks to two cognitive domains sensitive to age-related decline thought to rely on both common and distinct processes (executive function and episodic memory) in older adults. We quantified the cortical structure of individual functional network’s predictive ability and spatial extent (i.e., number of significant regions) with cognition and its mediating role in the age-cognition relationship. We found that cortical thickness, rather than surface area, predicted cognition across the majority of functional networks. The default mode and somatomotor network emerged as particularly important as they appeared to be the only two networks to mediate the age-cognition relationship for both cognitive domains. In contrast, thickness of the salience network predicted executive function and mediated the age-cognition relationship for executive function. These relationships remained significant even after accounting for global cortical thickness. Quantifying the number of regions related to cognition and mediating the age-cognition relationship yielded similar patterns of results. This study provides a potential approach to organize and describe the apparent widespread regional cortical structural relationships with cognition and age in older adults.

Suggested Citation

  • Michael B Kranz & Michelle W Voss & Gillian E Cooke & Sarah E Banducci & Agnieszka Z Burzynska & Arthur F Kramer, 2018. "The cortical structure of functional networks associated with age-related cognitive abilities in older adults," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-26, September.
  • Handle: RePEc:plo:pone00:0204280
    DOI: 10.1371/journal.pone.0204280
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    References listed on IDEAS

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    1. David C. Van Essen, 1997. "A tension-based theory of morphogenesis and compact wiring in the central nervous system," Nature, Nature, vol. 385(6614), pages 313-318, January.
    2. Hyunjin Park & Yeong-Hun Park & Jungho Cha & Sang Won Seo & Duk L Na & Jong-Min Lee, 2017. "Agreement between functional connectivity and cortical thickness-driven correlation maps of the medial frontal cortex," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-18, March.
    3. Michelle W Voss & Chelsea N Wong & Pauline L Baniqued & Jonathan H Burdette & Kirk I Erickson & Ruchika Shaurya Prakash & Edward McAuley & Paul J Laurienti & Arthur F Kramer, 2013. "Aging Brain from a Network Science Perspective: Something to Be Positive About?," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-14, November.
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    Cited by:

    1. Léonie Geissmann & David Coynel & Andreas Papassotiropoulos & Dominique J. F. Quervain, 2023. "Neurofunctional underpinnings of individual differences in visual episodic memory performance," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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