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Health care costs of influenza-related episodes in high income countries: A systematic review

Author

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  • Carlo Federici
  • Marianna Cavazza
  • Francesco Costa
  • Claudio Jommi

Abstract

Introduction: This study systematically reviews costing studies of seasonal influenza-like illness (ILI) in high-income countries. Existing reviews on the economic impact of ILI do not report information on drug consumption and its costs, nor do they provide data on the overall cost per episode. Methods: The PRISMA-P checklist was used to design the research protocol. Studies included were cost of illness analysis (COI) and modeling studies that estimated the cost of ILI episodes. Records were searched from January 2000 to December 2016 in electronic bibliographic databases including Medline, Embase, Science Direct, the Cochrane Library, the Centre for Reviews and Disseminations of the University of York, and Google scholar. References from the included studies were hand-searched for completion. Abstract screening, full-text analysis and data extraction were performed by two reviewers independently and discrepancies were resolved by discussion with a third reviewer. A standardized, pre-piloted form was used for data extraction. All costs were converted to 2015 US$ Purchasing Power Parities. Results: The literature search identified 5,104 records. After abstract and title screening, 76 studies were analyzed full-text and 27 studies were finally included in the review. Full estimates of the cost per episode range from US$19 in Korea to US$323 in Germany. Particularly, the cost per episode of laboratory confirmed influenza cases was estimated between US$64 and US$73. Inpatient and outpatient services account for the majority of the costs. Differences in the estimates may reflect country-specific characteristics, as well as other study-specific features including study design, identification strategy of ILI cases, study populations and types of costs included in the analysis. Children usually register higher costs, whereas evidence for the elderly is less conclusive. Patients risk-profile, co-morbidities and complications are the other important cost-drivers. None of the papers considered appropriateness in resource use (e.g. abuse of antibiotics). Despite cost of illness studies have ultimately a descriptive role, evidence on (in)appropriateness is useful for policy-makers.

Suggested Citation

  • Carlo Federici & Marianna Cavazza & Francesco Costa & Claudio Jommi, 2018. "Health care costs of influenza-related episodes in high income countries: A systematic review," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-15, September.
  • Handle: RePEc:plo:pone00:0202787
    DOI: 10.1371/journal.pone.0202787
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    References listed on IDEAS

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    1. Sudeep Karve & Derek Misurski & Guillermo Herrera-Taracena & Keith Davis, 2013. "Annual All-Cause Healthcare Costs Among Influenza Patients With and Without Influenza-Related Complications," Applied Health Economics and Health Policy, Springer, vol. 11(2), pages 119-128, April.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    3. Jennifer Haas & Sebastian Braun & Peter Wutzler, 2016. "Burden of influenza in Germany: a retrospective claims database analysis for the influenza season 2012/2013," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 17(6), pages 669-679, July.
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    1. Giovanna Elisa Calabrò & Sara Boccalini & Donatella Panatto & Caterina Rizzo & Maria Luisa Di Pietro & Fasika Molla Abreha & Marco Ajelli & Daniela Amicizia & Angela Bechini & Irene Giacchetta & Piero, 2022. "The New Quadrivalent Adjuvanted Influenza Vaccine for the Italian Elderly: A Health Technology Assessment," IJERPH, MDPI, vol. 19(7), pages 1-14, March.
    2. Kiana Wilkins, 2022. "Intersectional Immunity? Examining How Race/Ethnicity and Sexual Orientation Combine to Shape Influenza Vaccination Among US Adults," Population Research and Policy Review, Springer;Southern Demographic Association (SDA), vol. 41(6), pages 2585-2612, December.
    3. Mercè Soler-Font & Ignacio Aznar-Lou & Luca Basile & Núria Soldevila & Pere Godoy & Ana Martínez & Antoni Serrano-Blanco & Angela Domínguez & The Surveillance of Hospitalized Cases of Severe Influenza, 2022. "Costs and Factors Associated with Hospitalizations Due to Severe Influenza in Catalonia (2017–2020)," IJERPH, MDPI, vol. 19(22), pages 1-10, November.
    4. Sierk D. Marbus & Valentijn A. Schweitzer & Geert H. Groeneveld & Jan J. Oosterheert & Peter M. Schneeberger & Wim Hoek & Jaap T. Dissel & Arianne B. Gageldonk-Lafeber & Marie-Josée Mangen, 2020. "Incidence and costs of hospitalized adult influenza patients in The Netherlands: a retrospective observational study," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(5), pages 775-785, July.

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