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Predictors of noncompliance to pulmonary tuberculosis treatment: An insight from South America

Author

Listed:
  • Samanta Madeira de Oliveira
  • Stephan Altmayer
  • Matheus Zanon
  • Luzielio Alves Sidney-Filho
  • Ana Luiza Schneider Moreira
  • Paulo de Tarso Dalcin
  • Anderson Garcez
  • Bruno Hochhegger
  • José da Silva Moreira
  • Guilherme Watte

Abstract

Purpose: To investigate the factors associated with a higher risk of noncompliance to tuberculosis (TB) treatment in Porto Alegre, Brazil. Methods: We identified 478 adult patients for this case-control study undergoing treatment for confirmed pulmonary TB. Cases (noncompliance) were defined as patients who stopped treatment for more than 30 consecutive days (n = 118). Controls were defined as all patients who completed treatment and were cured (n = 360). Factors associated with noncompliance were calculated with unadjusted and adjusted odds ratio (OR). Results: The rate of noncompliance in our study was 25%. The factors of noncompliance after adjustments in the overall population were, in order of magnitude, living in an area of lower income (OR = 4.35, 95%CI: 2.50–7.58), abuse of drugs (OR = 2.73, 95%CI: 1.47–5.09), nonadherence to a previous treatment regimen (OR = 2.1, 95%CI: 1.28–3.45), and history of smoking (OR = 1.72, 95%CI: 1.00–3.00). Age, race, gender, level of education, HIV infection or diabetes status were not associated with a higher risk of noncompliance. In the subgroup of re-treatment cases, poverty (OR = 2.65; 95%CI = 1.06–6.66), smoking history (OR = 2.94; 95%CI = 1.09–7.92), male gender (OR = 3.25; 95%CI = 1.32–8.0), and younger age (OR = 4.3; 95%CI = 1.15–16.07) were also associated with a higher risk of dropout. Conclusion: Predictors of poor compliance to TB treatment were low income, abuse of drugs, re-treatment cases and history of smoking.

Suggested Citation

  • Samanta Madeira de Oliveira & Stephan Altmayer & Matheus Zanon & Luzielio Alves Sidney-Filho & Ana Luiza Schneider Moreira & Paulo de Tarso Dalcin & Anderson Garcez & Bruno Hochhegger & José da Silva , 2018. "Predictors of noncompliance to pulmonary tuberculosis treatment: An insight from South America," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-10, September.
    • Handle: RePEc:plo:pone00:0202593
    DOI: 10.1371/journal.pone.0202593
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    References listed on IDEAS

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    1. Liefooghe, R. & Michiels, N. & Habib, S. & Moran, M. B. & De Muynck, A., 1995. "Perception and social consequences of tuberculosis: A focus group study of tuberculosis patients in Sialkot, Pakistan," Social Science & Medicine, Elsevier, vol. 41(12), pages 1685-1692, December.
    2. Salla A Munro & Simon A Lewin & Helen J Smith & Mark E Engel & Atle Fretheim & Jimmy Volmink, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," PLOS Medicine, Public Library of Science, vol. 4(7), pages 1-16, July.
    3. Salla A Munro, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," Working Papers id:1107, eSocialSciences.
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