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Impact of tuberculosis treatment length and adherence under different transmission intensities

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  • Pinho, S.T.R.
  • Rodrigues, P.
  • Andrade, R.F.S.
  • Serra, H.
  • Lopes, J.S.
  • Gomes, M.G.M.

Abstract

Tuberculosis (TB) is a leading cause of human mortality due to infectious disease. Treatment default is a relevant factor which reduces therapeutic success and increases the risk of resistant TB. In this work we analyze the relation between treatment default and treatment length along with its consequence on the disease spreading. We use a stylized model structure to explore, systematically, the effects of varying treatment duration and compliance. We find that shortening treatment alone may not reduce TB prevalence, especially in regions where transmission intensity is high, indicating the necessity of complementing this action with increased compliance. A family of default functions relating the proportion of defaulters to the treatment length is considered and adjusted to a particular dataset. We find that the epidemiological benefits of shorter treatment regimens are tightly associated with increases in treatment compliance and depend on the epidemiological background.

Suggested Citation

  • Pinho, S.T.R. & Rodrigues, P. & Andrade, R.F.S. & Serra, H. & Lopes, J.S. & Gomes, M.G.M., 2015. "Impact of tuberculosis treatment length and adherence under different transmission intensities," Theoretical Population Biology, Elsevier, vol. 104(C), pages 68-77.
    • Handle: RePEc:eee:thpobi:v:104:y:2015:i:c:p:68-77
    DOI: 10.1016/j.tpb.2015.06.004
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    References listed on IDEAS

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    1. Salla A Munro, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," Working Papers id:1107, eSocialSciences.
    2. Salla A Munro & Simon A Lewin & Helen J Smith & Mark E Engel & Atle Fretheim & Jimmy Volmink, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," PLOS Medicine, Public Library of Science, vol. 4(7), pages 1-16, July.
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