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Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data

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  • Titilola Makanjuola
  • Henock B Taddese
  • Andrew Booth

Abstract

Objective: To systematically identify from qualitative data in the published literature the main barriers to adherence to isoniazid preventive therapy (IPT) for tuberculosis (TB) among people living with HIV/AIDS (PLWHA). Methods: We searched ten data sources, including MEDLINE and EMBASE for articles published in peer-reviewed journals from inception through to December 2011 for evidence relevant to IPT for TB in relation to PLWHA. Studies were assessed for quality using the CASP critical appraisal tool for qualitative studies. Data extracted from studies were then analysed thematically using thematic synthesis. Results: Eight studies, two of which were conducted within the same clinical trial, met the inclusion criteria. In addition to the influence of personal characteristics, five overarching themes were identified: Individual personal beliefs; HIV treatment and related issues; Socio-economic factors; Family and other social support factors, and Relationships with health providers. The review confirms current understanding of adherence to treatment as influenced by patients' understanding of, and beliefs related to treatment regimens. This is in-turn influenced by broader factors, namely: socio-economic factors such as poverty and lack of health facilities; the level of support available to patients from family and other networks and the stigma that emanates from these relationships; and relationships with health providers, which in-turn become a delicate issue given the sensitivity of dealing with two chronic diseases of significant morbidity and mortality toll. HIV treatment related issues also influence adherence to IPT, whereby challenges related to the acceptance, organisation and administration of these two long-term treatment regimens and stigma related to HIV/AIDS, are seen to be major factors. Conclusion: Understanding this complex interplay of factors more clearly is essential for healthcare decision-makers to be able to achieve the level of adherence required to effectively mitigate the threat posed by co-infection with TB and HIV/AIDS in developing countries.

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  • Titilola Makanjuola & Henock B Taddese & Andrew Booth, 2014. "Factors Associated with Adherence to Treatment with Isoniazid for the Prevention of Tuberculosis amongst People Living with HIV/AIDS: A Systematic Review of Qualitative Data," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0087166
    DOI: 10.1371/journal.pone.0087166
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    References listed on IDEAS

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    1. Deborah A Gust & Barudi Mosimaneotsile & Unami Mathebula & Balladiah Chingapane & Zaneta Gaul & Sherri L Pals & Taraz Samandari, 2011. "Risk Factors for Non-Adherence and Loss to Follow-Up in a Three-Year Clinical Trial in Botswana," PLOS ONE, Public Library of Science, vol. 6(4), pages 1-9, April.
    2. Salla A Munro & Simon A Lewin & Helen J Smith & Mark E Engel & Atle Fretheim & Jimmy Volmink, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," PLOS Medicine, Public Library of Science, vol. 4(7), pages 1-16, July.
    3. Salla A Munro, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," Working Papers id:1107, eSocialSciences.
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    1. Dawit Getachew Assefa & Eden Dagnachew Zeleke & Delayehu Bekele & Dawit A. Ejigu & Wondwosen Molla & Tigist Tekle Woldesenbet & Amdehiwot Aynalem & Mesfin Abebe & Andualem Mebratu & Tsegahun Manyazewa, 2022. "Isoniazid Preventive Therapy for Prevention of Tuberculosis among People Living with HIV in Ethiopia: A Systematic Review of Implementation and Impacts," IJERPH, MDPI, vol. 20(1), pages 1-12, December.
    2. Michael Scolarici & Ken Dekitani & Ling Chen & Marcia Sokol-Anderson & Daniel F Hoft & Soumya Chatterjee, 2018. "A scoring strategy for progression risk and rates of treatment completion in subjects with latent tuberculosis," PLOS ONE, Public Library of Science, vol. 13(11), pages 1-12, November.

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