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Challenges of Loss to Follow-up in Tuberculosis Research

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  • Thomas N Nissen
  • Michala V Rose
  • Godfather Kimaro
  • Ib C Bygbjerg
  • Sayoki G Mfinanga
  • Pernille Ravn

Abstract

Background: In studies evaluating methods for diagnosing tuberculosis (TB), follow-up to verify the presence or absence of active TB is crucial and high dropout rates may significantly affect the validity of the results. In a study assessing the diagnostic performance of the QuantiFERON®-TB Gold In-Tube test in TB suspect children in Tanzania, factors influencing patient adherence to attend follow-up examinations and reasons for not attending were examined. Methods: In 160 children who attended and 102 children who did not attend scheduled 2-month follow-up baseline health characteristics, demographic data and risk factors for not attending follow-up were determined. Qualitative interviews were used to understand patient and caretakers reasons for not returning for scheduled follow-up. Results: Being treated for active TB in the DOTS program (OR: 4.14; 95% CI:1.99–8.62;p-value 100;P-value

Suggested Citation

  • Thomas N Nissen & Michala V Rose & Godfather Kimaro & Ib C Bygbjerg & Sayoki G Mfinanga & Pernille Ravn, 2012. "Challenges of Loss to Follow-up in Tuberculosis Research," PLOS ONE, Public Library of Science, vol. 7(7), pages 1-8, July.
    • Handle: RePEc:plo:pone00:0040183
    DOI: 10.1371/journal.pone.0040183
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    References listed on IDEAS

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    1. Pace, C. & Talisuna, A. & Wendler, D. & Maiso, F. & Wabwire-Mangen, F. & Bakyaita, N. & Okiria, E. & Garrett-Mayer, E.S. & Emanuel, E. & Grady, C., 2005. "Quality of parental consent in a Ugandan malaria study," American Journal of Public Health, American Public Health Association, vol. 95(7), pages 1184-1189.
    2. Martin W G Brinkhof & Mar Pujades-Rodriguez & Matthias Egger, 2009. "Mortality of Patients Lost to Follow-Up in Antiretroviral Treatment Programmes in Resource-Limited Settings: Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 4(6), pages 1-9, June.
    3. Salla A Munro & Simon A Lewin & Helen J Smith & Mark E Engel & Atle Fretheim & Jimmy Volmink, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," PLOS Medicine, Public Library of Science, vol. 4(7), pages 1-16, July.
    4. Salla A Munro, 2007. "Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research," Working Papers id:1107, eSocialSciences.
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    Cited by:

    1. Alipio, Mark, 2020. "Determinants of tuberculosis incidence in East Asia and Pacific: A panel regression analysis," EconStor Preprints 215784, ZBW - Leibniz Information Centre for Economics.

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