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Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer

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  • Guo-dong Cao
  • Xing-yu Xu
  • Jia-wei Zhang
  • Bo Chen
  • Mao-ming Xiong

Abstract

Aims: The mammalian target of rapamycin (mTOR) and phosphorylated mTOR (p-mTOR) occurring downstream in the PI3K/Akt/mTOR pathway, are regarded as potential prognostic markers for gastric cancer (GC). However, the prognostic value of mTOR/p-mTOR expression remains controversial. In this study, we determined the expression of mTOR, p-mTOR, p70S6k, and p-p70S6K in GC, and investigated the correlation between their overexpression, clinicopathological parameters, and overall survival (OS). Methods: The expression of mTOR, p-mTOR, p70S6k, and p-p70S6K was examined in 120 GC patients by immunohistochemistry (IHC). The association of protein expression with clinicopathological features and OS was explored. The p-mTOR expression was detected in normal, adjacent, and GC tissues using Western blot. Eligible studies retrieved from PubMed, Ovid, Web of Science and Cochrane databases, were reviewed in this meta-analysis. Results: IHC showed that the rates of expression of the signal transduction molecules mTOR, p-mTOR, p70S6k and p-p70S6K in GC were 60.8%, 54.2%, 53.3% and 53.3%, respectively. Overexpression of mTOR and p70S6K showed no significant association with clinical variables. Expression of p-mTOR was significantly associated with differentiation (P 0.05). Furthermore, p-mTOR and p-p70S6K expression, but not mTOR and p70S6K, were tightly associated with OS of GC patients (P = 0.006 and P

Suggested Citation

  • Guo-dong Cao & Xing-yu Xu & Jia-wei Zhang & Bo Chen & Mao-ming Xiong, 2016. "Phosphorylated Mammalian Target of Rapamycin p-mTOR Is a Favorable Prognostic Factor than mTOR in Gastric Cancer," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-16, December.
    • Handle: RePEc:plo:pone00:0168085
    DOI: 10.1371/journal.pone.0168085
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    1. Andrew C. Hsieh & Yi Liu & Merritt P. Edlind & Nicholas T. Ingolia & Matthew R. Janes & Annie Sher & Evan Y. Shi & Craig R. Stumpf & Carly Christensen & Michael J. Bonham & Shunyou Wang & Pingda Ren &, 2012. "The translational landscape of mTOR signalling steers cancer initiation and metastasis," Nature, Nature, vol. 485(7396), pages 55-61, May.
    2. Lei Li & Dan Liu & Zhi-Xin Qiu & Shuang Zhao & Li Zhang & Wei-Min Li, 2015. "The Prognostic Role of mTOR and P-mTOR for Survival in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(2), pages 1-13, February.
    3. Reuben J. Shaw & Lewis C. Cantley, 2006. "Ras, PI(3)K and mTOR signalling controls tumour cell growth," Nature, Nature, vol. 441(7092), pages 424-430, May.
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