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Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity

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  • Ming-Ling Chang
  • Chia-Jung Kuo
  • Hsin-Chih Huang
  • Yin-Yi Chu
  • Cheng-Tang Chiu

Abstract

Background: The association between leptin and complement in hepatitis C virus (HCV) infection remains unknown. Methods: A prospective study was conducted including 474 (250 genotype 1, 224 genotype 2) consecutive chronic hepatitis C (CHC) patients who had completed an anti-HCV therapy course and undergone pre-therapy and 24-week post-therapy assessments of interferon λ3-rs12979860 and HCV RNA/genotypes, anthropometric measurements, metabolic and liver profiles, and complement component 3 (C3), C4, and leptin levels. Results: Of the 474 patients, 395 had a sustained virological response (SVR). Pre-therapy leptin levels did not differ between patients with and without an SVR. Univariate and multivariate analyses showed that sex (pre- and post-therapy, p

Suggested Citation

  • Ming-Ling Chang & Chia-Jung Kuo & Hsin-Chih Huang & Yin-Yi Chu & Cheng-Tang Chiu, 2016. "Association between Leptin and Complement in Hepatitis C Patients with Viral Clearance: Homeostasis of Metabolism and Immunity," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-12, November.
    • Handle: RePEc:plo:pone00:0166712
    DOI: 10.1371/journal.pone.0166712
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    1. Graham M. Lord & Giuseppe Matarese & Jane K. Howard & Richard J. Baker & Stephen R. Bloom & Robert I. Lechler, 1998. "Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression," Nature, Nature, vol. 394(6696), pages 897-901, August.
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