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Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country

Author

Listed:
  • Sahal Al Hajoj
  • Bright Varghese
  • Alria Datijan
  • Mohammed Shoukri
  • Ali Alzahrani
  • Abdallah Alkhenizan
  • Abdulaziz AlSaif
  • Sahar Althawadi
  • Grace Fernandez
  • Abdulrahman Alrajhi

Abstract

Health care workers (HCW’s) are always at an increased risk of contracting tuberculosis (TB) infection. In Saudi Arabia, Interferon Gamma Release Assay (IGRA) has not been evaluated as a screening tool for latent TB infection (LTBI) among HCW’s considering their high demographic diversity. During February 2012 to January 2015 a cross sectional study has been conducted in a tertiary care center with maximum demographically diverse staff population in the capital city-Riyadh. After a short interview and consenting, all the candidates were subjected to tuberculin skin test (TST) and QuantiFERON TB gold In-tube test (QFT). A logistic regression analysis was carried out for establishing the associations between putative risk factors and the diagnostic tests. The candidates were classified according to geographical origin and a detailed analysis was conducted on the impact of their origin towards the results of TST and QFT. Of the 1595 candidates enrolled, 90.6% were BCG vaccinated, female (67.9%) and mainly nurses (53.2%). Candidates with high risk of suspected or confirmed TB patient exposure were 56.1% and 76.5% of them had

Suggested Citation

  • Sahal Al Hajoj & Bright Varghese & Alria Datijan & Mohammed Shoukri & Ali Alzahrani & Abdallah Alkhenizan & Abdulaziz AlSaif & Sahar Althawadi & Grace Fernandez & Abdulrahman Alrajhi, 2016. "Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0154803
    DOI: 10.1371/journal.pone.0154803
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    References listed on IDEAS

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    1. Rajnish Joshi & Arthur L Reingold & Dick Menzies & Madhukar Pai, 2006. "Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 3(12), pages 1-16, December.
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    1. Claudia Peters & Agnessa Kozak & Albert Nienhaus & Anja Schablon, 2020. "Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries—A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 17(2), pages 1-16, January.

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