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Prevalence and Incidence of Latent Tuberculosis Infection in Georgian Healthcare Workers

Author

Listed:
  • Jennifer A. Whitaker
  • Veriko Mirtskhulava
  • Maia Kipiani
  • Drew A Harris
  • Nino Tabagari
  • Russell R Kempker
  • Henry M Blumberg

Abstract

Background: Tuberculosis is a major occupational hazard in low and middle-income countries. Limited data exist on serial testing of healthcare workers (HCWs) with interferon-γ release assays (IGRAs) for latent tuberculosis infection (LTBI), especially in low and middle-income countries. We sought to evaluate the rates of and risk factors for LTBI prevalence and LTBI test conversion among HCWs using the tuberculin skin test (TST) and QuantiFERON-TB Gold In-tube assay (QFT-GIT). Methods: A prospective longitudinal study was conducted among HCWs in the country of Georgia. Subjects completed a questionnaire, and TST and QFT-GIT tests were performed. LTBI testing was repeated 6-26 months after baseline testing. Results: Among 319 HCWs enrolled, 89% reported prior BCG vaccination, and 60% worked in TB healthcare facilities (HCFs). HCWs from TB HCFs had higher prevalence of positive QFT-GIT and TST than those from non-TB HCFs: 107/194 (55%) vs. 30/125 (31%) QFT-GIT positive (p

Suggested Citation

  • Jennifer A. Whitaker & Veriko Mirtskhulava & Maia Kipiani & Drew A Harris & Nino Tabagari & Russell R Kempker & Henry M Blumberg, 2013. "Prevalence and Incidence of Latent Tuberculosis Infection in Georgian Healthcare Workers," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0058202
    DOI: 10.1371/journal.pone.0058202
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    References listed on IDEAS

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    1. Rajnish Joshi & Arthur L Reingold & Dick Menzies & Madhukar Pai, 2006. "Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 3(12), pages 1-16, December.
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    1. Bin Chen & Xiaomeng Wang & Jiemin Zhong & Songhua Chen & Beibei Wu & Hui-Chi Yeh & Zhenggang Jiang & Zhengting Wang & Hua Gu & Jianmin Jiang, 2014. "Tuberculosis among Healthcare Workers in Southeastern China: A Retrospective Study of 7-Year Surveillance Data," IJERPH, MDPI, vol. 11(11), pages 1-11, November.
    2. Rajni Rai & Sonia El-Zaemey & Nidup Dorji & Bir Doj Rai & Lin Fritschi, 2021. "Exposure to Occupational Hazards among Health Care Workers in Low- and Middle-Income Countries: A Scoping Review," IJERPH, MDPI, vol. 18(5), pages 1-41, March.
    3. Tsira Chakhaia & Matthew J Magee & Russell R Kempker & Medea Gegia & Leila Goginashvili & Ucha Nanava & Henry M Blumberg, 2014. "High Utility of Contact Investigation for Latent and Active Tuberculosis Case Detection among the Contacts: A Retrospective Cohort Study in Tbilisi, Georgia, 2010–2011," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.

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