IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0058202.html
   My bibliography  Save this article

Prevalence and Incidence of Latent Tuberculosis Infection in Georgian Healthcare Workers

Author

Listed:
  • Jennifer A. Whitaker
  • Veriko Mirtskhulava
  • Maia Kipiani
  • Drew A Harris
  • Nino Tabagari
  • Russell R Kempker
  • Henry M Blumberg

Abstract

Background: Tuberculosis is a major occupational hazard in low and middle-income countries. Limited data exist on serial testing of healthcare workers (HCWs) with interferon-γ release assays (IGRAs) for latent tuberculosis infection (LTBI), especially in low and middle-income countries. We sought to evaluate the rates of and risk factors for LTBI prevalence and LTBI test conversion among HCWs using the tuberculin skin test (TST) and QuantiFERON-TB Gold In-tube assay (QFT-GIT). Methods: A prospective longitudinal study was conducted among HCWs in the country of Georgia. Subjects completed a questionnaire, and TST and QFT-GIT tests were performed. LTBI testing was repeated 6-26 months after baseline testing. Results: Among 319 HCWs enrolled, 89% reported prior BCG vaccination, and 60% worked in TB healthcare facilities (HCFs). HCWs from TB HCFs had higher prevalence of positive QFT-GIT and TST than those from non-TB HCFs: 107/194 (55%) vs. 30/125 (31%) QFT-GIT positive (p

Suggested Citation

  • Jennifer A. Whitaker & Veriko Mirtskhulava & Maia Kipiani & Drew A Harris & Nino Tabagari & Russell R Kempker & Henry M Blumberg, 2013. "Prevalence and Incidence of Latent Tuberculosis Infection in Georgian Healthcare Workers," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-8, March.
    • Handle: RePEc:plo:pone00:0058202
    DOI: 10.1371/journal.pone.0058202
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058202
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0058202&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0058202?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Rajnish Joshi & Arthur L Reingold & Dick Menzies & Madhukar Pai, 2006. "Tuberculosis among Health-Care Workers in Low- and Middle-Income Countries: A Systematic Review," PLOS Medicine, Public Library of Science, vol. 3(12), pages 1-16, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Rajni Rai & Sonia El-Zaemey & Nidup Dorji & Bir Doj Rai & Lin Fritschi, 2021. "Exposure to Occupational Hazards among Health Care Workers in Low- and Middle-Income Countries: A Scoping Review," IJERPH, MDPI, vol. 18(5), pages 1-41, March.
    2. Bin Chen & Xiaomeng Wang & Jiemin Zhong & Songhua Chen & Beibei Wu & Hui-Chi Yeh & Zhenggang Jiang & Zhengting Wang & Hua Gu & Jianmin Jiang, 2014. "Tuberculosis among Healthcare Workers in Southeastern China: A Retrospective Study of 7-Year Surveillance Data," IJERPH, MDPI, vol. 11(11), pages 1-11, November.
    3. Tsira Chakhaia & Matthew J Magee & Russell R Kempker & Medea Gegia & Leila Goginashvili & Ucha Nanava & Henry M Blumberg, 2014. "High Utility of Contact Investigation for Latent and Active Tuberculosis Case Detection among the Contacts: A Retrospective Cohort Study in Tbilisi, Georgia, 2010–2011," PLOS ONE, Public Library of Science, vol. 9(11), pages 1-9, November.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Halim Ismail & Naiemy Reffin & Sharifa Ezat Wan Puteh & Mohd Rohaizat Hassan, 2021. "Compliance of Healthcare Worker’s toward Tuberculosis Preventive Measures in Workplace: A Systematic Literature Review," IJERPH, MDPI, vol. 18(20), pages 1-21, October.
    2. Sommerland, Nina & Masquillier, Caroline & Rau, Asta & Engelbrecht, Michelle & Kigozi, Gladys & Pliakas, Triantafyllos & Janse van Rensburg, Andre & Wouters, Edwin, 2020. "Reducing HIV- and TB-Stigma among healthcare co-workers in South Africa: Results of a cluster randomised trial," Social Science & Medicine, Elsevier, vol. 266(C).
    3. Bingke Zhu & Hao Fan & Bingbing Xie & Ran Su & Chaofeng Zhou & Jianping He, 2020. "Mapping the Scientific Research on Healthcare Workers’ Occupational Health: A Bibliometric and Social Network Analysis," IJERPH, MDPI, vol. 17(8), pages 1-22, April.
    4. Anna Rita Corvino & Maria Grazia Lourdes Monaco & Elpidio Maria Garzillo & Elena Grimaldi & Giovanna Donnarumma & Nadia Miraglia & Gabriella Di Giuseppe & Monica Lamberti, 2020. "Tuberculosis Infection Screening in 5468 Italian Healthcare Students: Investigation of a Borderline Zone Value for the QFT-Test," IJERPH, MDPI, vol. 17(18), pages 1-9, September.
    5. Tolu Oni & Hannah P Gideon & Nonzwakazi Bangani & Relebohile Tsekela & Ronnett Seldon & Kathryn Wood & Katalin A Wilkinson & Rene T Goliath & Tom H M Ottenhoff & Robert J Wilkinson, 2012. "Smoking, BCG and Employment and the Risk of Tuberculosis Infection in HIV-Infected Persons in South Africa," PLOS ONE, Public Library of Science, vol. 7(10), pages 1-5, October.
    6. Xia Zhang & Hongyan Jia & Fei Liu & Liping Pan & Aiying Xing & Shuxiang Gu & Boping Du & Qi Sun & Rongrong Wei & Zongde Zhang, 2013. "Prevalence and Risk Factors for Latent Tuberculosis Infection among Health Care Workers in China: A Cross-Sectional Study," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-6, June.
    7. Rajni Rai & Sonia El-Zaemey & Nidup Dorji & Bir Doj Rai & Lin Fritschi, 2021. "Exposure to Occupational Hazards among Health Care Workers in Low- and Middle-Income Countries: A Scoping Review," IJERPH, MDPI, vol. 18(5), pages 1-41, March.
    8. Jennica Garnett & David Jones & Graham Chin & Jerry M. Spiegel & Annalee Yassi & Nisha Naicker, 2020. "Occupational Tuberculosis Among Laboratory Workers in South Africa: Applying a Surveillance System to Strengthen Prevention and Control," IJERPH, MDPI, vol. 17(5), pages 1-12, February.
    9. Dikeledi O. Matuka & Thabang Duba & Zethembiso Ngcobo & Felix Made & Lufuno Muleba & Tebogo Nthoke & Tanusha S. Singh, 2021. "Occupational Risk of Airborne Mycobacterium tuberculosis Exposure: A Situational Analysis in a Three-Tier Public Healthcare System in South Africa," IJERPH, MDPI, vol. 18(19), pages 1-15, September.
    10. Thanthun Sangphoo & Naesinee Chaiear & Patimaporn Chanpho, 2020. "Work-Related Tuberculosis among Health Workers Employed in a Tertiary Hospital in Northeastern Thailand: A Report of Nine Cases," IJERPH, MDPI, vol. 17(14), pages 1-8, July.
    11. Sahal Al Hajoj & Bright Varghese & Alria Datijan & Mohammed Shoukri & Ali Alzahrani & Abdallah Alkhenizan & Abdulaziz AlSaif & Sahar Althawadi & Grace Fernandez & Abdulrahman Alrajhi, 2016. "Interferon Gamma Release Assay versus Tuberculin Skin Testing among Healthcare Workers of Highly Diverse Origin in a Moderate Tuberculosis Burden Country," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-11, May.
    12. Rajnish Joshi & Samir Patil & Shriprakash Kalantri & Kevin Schwartzman & Dick Menzies & Madhukar Pai, 2007. "Prevalence of Abnormal Radiological Findings in Health Care Workers with Latent Tuberculosis Infection and Correlations with T Cell Immune Response," PLOS ONE, Public Library of Science, vol. 2(8), pages 1-9, August.
    13. Bin Chen & Xiaomeng Wang & Jiemin Zhong & Songhua Chen & Beibei Wu & Hui-Chi Yeh & Zhenggang Jiang & Zhengting Wang & Hua Gu & Jianmin Jiang, 2014. "Tuberculosis among Healthcare Workers in Southeastern China: A Retrospective Study of 7-Year Surveillance Data," IJERPH, MDPI, vol. 11(11), pages 1-11, November.
    14. Esther Vaquero-Álvarez & Antonio Cubero-Atienza & Pilar Ruiz-Martínez & Manuel Vaquero-Abellán & María Dolores Redel-Macías & Pilar Aparicio-Martínez, 2020. "Tuberculosis and Other Airborne Microbes in Occupational Health and Safety," IJERPH, MDPI, vol. 17(19), pages 1-16, September.
    15. Mohammad Hossein YektaKooshali & Farahnaz Movahedzadeh & Ali Alavi Foumani & Hoda Sabati & Alireza Jafari, 2019. "Is latent tuberculosis infection challenging in Iranian health care workers? A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-19, October.
    16. Nathan N O’Hara & Lilla Roy & Lyndsay M O’Hara & Jerry M Spiegel & Larry D Lynd & J Mark FitzGerald & Annalee Yassi & Letshego E Nophale & Carlo A Marra, 2015. "Healthcare Worker Preferences for Active Tuberculosis Case Finding Programs in South Africa: A Best-Worst Scaling Choice Experiment," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-13, July.
    17. Patimaporn Chanpho & Naesinee Chaiear & Supot Kamsa-ard, 2020. "Factors Associated with Latent Tuberculosis Infection among the Hospital Employees in a Tertiary Hospital of Northeastern Thailand," IJERPH, MDPI, vol. 17(18), pages 1-12, September.
    18. Mohajan, Haradhan, 2014. "Tuberculosis is a Fatal Disease among Some Developing Countries of the World," MPRA Paper 82851, University Library of Munich, Germany, revised 22 Jan 2015.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0058202. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.