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Prenatal, Perinatal and Neonatal Risk Factors for Intellectual Disability: A Systemic Review and Meta-Analysis

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  • Jichong Huang
  • Tingting Zhu
  • Yi Qu
  • Dezhi Mu

Abstract

Background: The etiology of non-genetic intellectual disability (ID) is not fully known, and we aimed to identify the prenatal, perinatal and neonatal risk factors for ID. Method: PubMed and Embase databases were searched for studies that examined the association between pre-, peri- and neonatal factors and ID risk (keywords “intellectual disability” or “mental retardation” or “ID” or “MR” in combination with “prenatal” or “pregnancy” or “obstetric” or “perinatal” or “neonatal”. The last search was updated on September 15, 2015. Summary effect estimates (pooled odds ratios) were calculated for each risk factor using random effects models, with tests for heterogeneity and publication bias. Results: Seventeen studies with 55,344 patients and 5,723,749 control individuals were eligible for inclusion in our analysis, and 16 potential risk factors were analyzed. Ten prenatal factors (advanced maternal age, maternal black race, low maternal education, third or more parity, maternal alcohol use, maternal tobacco use, maternal diabetes, maternal hypertension, maternal epilepsy and maternal asthma), one perinatal factor (preterm birth) and two neonatal factors (male sex and low birth weight) were significantly associated with increased risk of ID. Conclusion: This systemic review and meta-analysis provides a comprehensive evidence-based assessment of the risk factors for ID. Future studies are encouraged to focus on perinatal and neonatal risk factors and the combined effects of multiple factors.

Suggested Citation

  • Jichong Huang & Tingting Zhu & Yi Qu & Dezhi Mu, 2016. "Prenatal, Perinatal and Neonatal Risk Factors for Intellectual Disability: A Systemic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0153655
    DOI: 10.1371/journal.pone.0153655
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    1. Silvia Regina Dias Medici Saldiva & Ligia Vizeu Barrozo & Clea Rodrigues Leone & Marcelo Antunes Failla & Eliana De Aquino Bonilha & Regina Tomie Ivata Bernal & Regiani Carvalho de Oliveira & Paulo Hi, 2018. "Small-Scale Variations in Urban Air Pollution Levels Are Significantly Associated with Premature Births: A Case Study in São Paulo, Brazil," IJERPH, MDPI, vol. 15(10), pages 1-16, October.
    2. Michal Vostrý & Barbora Lanková & Ilona Pešatová & Otakar Fleischmann & Jaroslava Jelínková, 2022. "Nonpharmacological Compensation of Aggressive Behavior of Individuals with Moderate Intellectual Disability and Behavioral Disorders—A Case Study," IJERPH, MDPI, vol. 19(15), pages 1-12, July.
    3. Wafeeq Abdelaziz, Asmaa & Ibrahim Abdelmageed, Reham, 2021. "An overview of non-genetic intellectual disability among Egyptian children and adolescents," Children and Youth Services Review, Elsevier, vol. 127(C).
    4. Andrea K. Bowe & Anthony Staines & Deirdre M. Murray, 2021. "Below Average Cognitive Ability—An under Researched Risk Factor for Emotional-Behavioural Difficulties in Childhood," IJERPH, MDPI, vol. 18(24), pages 1-14, December.

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