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Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity

Author

Listed:
  • Sofus C Larsen
  • Lars Ängquist
  • Max Moldovan
  • Ville Huikari
  • Sylvain Sebert
  • Alana Cavadino
  • Tarunveer Singh Ahluwalia
  • Tea Skaaby
  • Allan Linneberg
  • Lise Lotte N Husemoen
  • Ulla Toft
  • Oluf Pedersen
  • Torben Hansen
  • Karl-Heinz Herzig
  • Marjo-Riitta Jarvelin
  • Chris Power
  • Elina Hyppönen
  • Berit L Heitmann
  • Thorkild I A Sørensen

Abstract

Studies of the relationship between serum 25-hydroxyvitamin D (25(OH)D) and changes in measures of adiposity have shown inconsistent results, and interaction with genetic predisposition to obesity has rarely been examined. We examined whether 25(OH)D was associated with subsequent annual changes in body weight (ΔBW) or waist circumference (ΔWC), and whether the associations were modified by genetic predisposition to a high BMI, WC or waist-hip ratio adjusted for BMI (WHRBMI). The study was based on 10,898 individuals from the Danish Inter99, the 1958 British Birth Cohort and the Northern Finland Birth Cohort 1966. We combined 42 adiposity-associated Single Nucleotide Polymorphisms (SNPs) into four scores indicating genetic predisposition to BMI, WC and WHRBMI, or all three traits combined. Linear regression was used to examine the association between serum 25(OH)D and ΔBW or ΔWC, SNP-score × 25(OH)D interactions were examined, and results from the individual cohorts were meta-analyzed. In the meta-analyses, we found no evidence of an association between 25(OH)D and ΔBW (-9.4 gram/y per 10 nmol/L higher 25(OH)D [95% CI: -23.0, +4.3; P = 0.18]) or ΔWC (-0.06 mm/y per 10 nmol/L higher 25(OH)D [95% CI: -0.17, +0.06; P = 0.33]). Furthermore, we found no statistically significant interactions between the four SNP-scores and 25(OH)D in relation to ΔBW or ΔWC. Thus, in view of the narrow CIs, our results suggest that an association between 25(OH)D and changes in measures of adiposity is absent or marginal. Similarly, the study provided evidence that there is either no or very limited dependence on genetic predisposition to adiposity.

Suggested Citation

  • Sofus C Larsen & Lars Ängquist & Max Moldovan & Ville Huikari & Sylvain Sebert & Alana Cavadino & Tarunveer Singh Ahluwalia & Tea Skaaby & Allan Linneberg & Lise Lotte N Husemoen & Ulla Toft & Oluf Pe, 2016. "Serum 25-Hydroxyvitamin D Status and Longitudinal Changes in Weight and Waist Circumference: Influence of Genetic Predisposition to Adiposity," PLOS ONE, Public Library of Science, vol. 11(4), pages 1-18, April.
    • Handle: RePEc:plo:pone00:0153611
    DOI: 10.1371/journal.pone.0153611
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    1. Karani S Vimaleswaran & Diane J Berry & Chen Lu & Emmi Tikkanen & Stefan Pilz & Linda T Hiraki & Jason D Cooper & Zari Dastani & Rui Li & Denise K Houston & Andrew R Wood & Karl Michaëlsson & Liesbeth, 2013. "Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts," PLOS Medicine, Public Library of Science, vol. 10(2), pages 1-13, February.
    2. Nancy L Heard-Costa & M Carola Zillikens & Keri L Monda & Åsa Johansson & Tamara B Harris & Mao Fu & Talin Haritunians & Mary F Feitosa & Thor Aspelund & Gudny Eiriksdottir & Melissa Garcia & Lenore J, 2009. "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-9, June.
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