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Interaction between Genetic Predisposition to Adiposity and Dietary Protein in Relation to Subsequent Change in Body Weight and Waist Circumference

Author

Listed:
  • Mikkel Z Ankarfeldt
  • Sofus C Larsen
  • Lars Ängquist
  • Lise Lotte N Husemoen
  • Nina Roswall
  • Kim Overvad
  • Marianne Uhre Jakobsen
  • Jytte Halkjær
  • Anne Tjønneland
  • Allan Linneberg
  • Ulla Toft
  • Torben Hansen
  • Oluf Pedersen
  • Berit L Heitmann
  • Arne Astrup
  • Thorkild I A Sørensen

Abstract

Background: Genetic predisposition to adiposity may interact with dietary protein in relation to changes of anthropometry. Objective: To investigate the interaction between genetic predisposition to higher body mass index (BMI), waist circumference (WC) or waist-hip ratio adjusted for BMI (WHRBMI) and dietary protein in relation to subsequent change in body weight (ΔBW) or change in WC (ΔWC). Design: Three different Danish cohorts were used. In total 7,054 individuals constituted the study population with information on diet, 50 single-nucleotide polymorphisms (SNPs) associated with BMI, WC or WHRBMI, as well as potential confounders. Mean follow-up time was ∼5 years. Four genetic predisposition-scores were based on the SNPs; a complete-score including all selected adiposity- associated SNPs, and three scores including BMI, WC or WHRBMI associated polymorphisms, respectively. The association between protein intake and ΔBW or ΔWC were examined and interactions between SNP-score and protein were investigated. Analyses were based on linear regressions using macronutrient substitution models and meta-analyses. Results: When protein replaced carbohydrate, meta-analyses showed no associations with ΔBW (41.0 gram/y/5 energy% protein, [95% CI: −32.3; 114.3]) or ΔWC (

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  • Mikkel Z Ankarfeldt & Sofus C Larsen & Lars Ängquist & Lise Lotte N Husemoen & Nina Roswall & Kim Overvad & Marianne Uhre Jakobsen & Jytte Halkjær & Anne Tjønneland & Allan Linneberg & Ulla Toft & Tor, 2014. "Interaction between Genetic Predisposition to Adiposity and Dietary Protein in Relation to Subsequent Change in Body Weight and Waist Circumference," PLOS ONE, Public Library of Science, vol. 9(10), pages 1-10, October.
    • Handle: RePEc:plo:pone00:0110890
    DOI: 10.1371/journal.pone.0110890
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    1. Nancy L Heard-Costa & M Carola Zillikens & Keri L Monda & Åsa Johansson & Tamara B Harris & Mao Fu & Talin Haritunians & Mary F Feitosa & Thor Aspelund & Gudny Eiriksdottir & Melissa Garcia & Lenore J, 2009. "NRXN3 Is a Novel Locus for Waist Circumference: A Genome-Wide Association Study from the CHARGE Consortium," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-9, June.
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