IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0144538.html
   My bibliography  Save this article

The Effect of Disease Modifying Therapies on Disease Progression in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis

Author

Listed:
  • Georgios Tsivgoulis
  • Aristeidis H Katsanos
  • Nikolaos Grigoriadis
  • Georgios M Hadjigeorgiou
  • Ioannis Heliopoulos
  • Panagiotis Papathanasopoulos
  • Constantinos Kilidireas
  • Konstantinos Voumvourakis
  • Efthimios Dardiotis
  • HELANI (Hellenic Academy of Neuroimmunology)

Abstract

Importance: A number of officially approved disease-modifying drugs (DMD) are currently available for the early intervention in patients with relapsing-remitting multiple sclerosis (RRMS). The aim of the present study was to systematically evaluate the effect of DMDs on disability progression in RRMS Methods: We performed a systematic review on MEDLINE and SCOPUS databases to include all available placebo-controlled randomized clinical trials (RCTs) of RRMS patients that reported absolute numbers or percentages of disability progression during each study period. Observational studies, case series, case reports, RCTs without placebo subgroups and studies reporting the use of RRMS therapies that are not still officially approved were excluded. Risk ratios (RRs) were calculated in each study protocol to express the comparison of disability progression in RRMS patients treated with a DMD and those RRMS patients receiving placebo. The mixed-effects model was used to calculate both the pooled point estimate in each subgroup and the overall estimates. Results: DMDs for RRMS were found to have a significantly lower risk of disability progression compared to placebo (RR = 0.72, 95%CI: 0.66–0.79; p 20%) rates of loss to follow-up were reported in many study protocols, while financial and/or other support from pharmaceutical industries with a clear conflict of interest on the study outcomes was documented in all included studies. Conclusions: Available DMD are effective in reducing disability progression in patients with RRMS, independently of the route of administration and their classification as “first” or “second” line therapies. Attrition bias needs to be taken into account in the interpretation of these findings.

Suggested Citation

  • Georgios Tsivgoulis & Aristeidis H Katsanos & Nikolaos Grigoriadis & Georgios M Hadjigeorgiou & Ioannis Heliopoulos & Panagiotis Papathanasopoulos & Constantinos Kilidireas & Konstantinos Voumvourakis, 2015. "The Effect of Disease Modifying Therapies on Disease Progression in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-12, December.
    • Handle: RePEc:plo:pone00:0144538
    DOI: 10.1371/journal.pone.0144538
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144538
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144538&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0144538?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Georgios Tsivgoulis & Aristeidis H Katsanos & Nikolaos Grigoriadis & Georgios M Hadjigeorgiou & Ioannis Heliopoulos & Constantinos Kilidireas & Konstantinos Voumvourakis, 2015. "The Effect of Disease Modifying Therapies on Brain Atrophy in Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-10, March.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Georgios Tsivgoulis & Aristeidis H Katsanos & Dimitris Mavridis & Nikolaos Grigoriadis & Efthymios Dardiotis & Ioannis Heliopoulos & Panagiotis Papathanasopoulos & Theodoros Karapanayiotides & Constan, 2016. "The Efficacy of Natalizumab versus Fingolimod for Patients with Relapsing-Remitting Multiple Sclerosis: A Systematic Review, Indirect Evidence from Randomized Placebo-Controlled Trials and Meta-Analys," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-14, September.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Tripathy, Prajukta & Jena, Pabitra Kumar & Mishra, Bikash Ranjan, 2024. "Systematic literature review and bibliometric analysis of energy efficiency," Renewable and Sustainable Energy Reviews, Elsevier, vol. 200(C).
    2. Elizabeth T Cafiero-Fonseca & Andrew Stawasz & Sydney T Johnson & Reiko Sato & David E Bloom, 2017. "The full benefits of adult pneumococcal vaccination: A systematic review," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-23, October.
    3. Ludoviko Zirimenya & Fatima Mahmud-Ajeigbe & Ruth McQuillan & You Li, 2020. "A systematic review and meta-analysis to assess the association between urogenital schistosomiasis and HIV/AIDS infection," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(6), pages 1-13, June.
    4. Trang Nguyen & Sara Holton & Thach Tran & Jane Fisher, 2019. "Informal mental health interventions for people with severe mental illness in low and lower middle-income countries: A systematic review of effectiveness," International Journal of Social Psychiatry, , vol. 65(3), pages 194-206, May.
    5. Natalya Ivanova & Ekaterina Zolotova, 2023. "Landolt Indicator Values in Modern Research: A Review," Sustainability, MDPI, vol. 15(12), pages 1-22, June.
    6. Su Keng Tan & Wai Keung Leung & Alexander Tin Hong Tang & Roger A Zwahlen, 2017. "Effects of mandibular setback with or without maxillary advancement osteotomies on pharyngeal airways: An overview of systematic reviews," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-20, October.
    7. Vecchio, Riccardo & Caso, Gerarda & Cembalo, Luigi & Borrello, Massimiliano, 2020. "Is respondents’ inattention in online surveys a major issue for research?," Economia agro-alimentare / Food Economy, Italian Society of Agri-food Economics/Società Italiana di Economia Agro-Alimentare (SIEA), vol. 22(1), March.
    8. Alessandro Concari & Gerjo Kok & Pim Martens, 2020. "A Systematic Literature Review of Concepts and Factors Related to Pro-Environmental Consumer Behaviour in Relation to Waste Management Through an Interdisciplinary Approach," Sustainability, MDPI, vol. 12(11), pages 1-50, May.
    9. Damiano Pizzol & Mike Trott & Igor Grabovac & Mario Antunes & Anna Claudia Colangelo & Simona Ippoliti & Cristian Petre Ilie & Anne Carrie & Nicola Veronese & Lee Smith, 2021. "Laparoscopy in Low-Income Countries: 10-Year Experience and Systematic Literature Review," IJERPH, MDPI, vol. 18(11), pages 1-11, May.
    10. Yehuda Weizman & Oren Tirosh & Jeanie Beh & Franz Konstantin Fuss & Sonja Pedell, 2021. "Gait Assessment Using Wearable Sensor-Based Devices in People Living with Dementia: A Systematic Review," IJERPH, MDPI, vol. 18(23), pages 1-14, December.
    11. Alessandro Margherita & Emanuele Banchi & Alfredo Biffi & Gianluca di Castri & Rocco Morelli, 2022. "Beyond Total Cost Management (TCM) to Systemic Value Management (SVM): Transformational Trends and a Research Manifesto for an Evolving Discipline," Sustainability, MDPI, vol. 14(19), pages 1-16, October.
    12. Stefano D’Angelo & Angelo Cavallo & Antonio Ghezzi & Francesco Di Lorenzo, 2024. "Understanding corporate entrepreneurship in the digital age: a review and research agenda," Review of Managerial Science, Springer, vol. 18(12), pages 3719-3774, December.
    13. Fabio Magnacca & Riccardo Giannetti, 2024. "Management accounting and new product development: a systematic literature review and future research directions," Journal of Management & Governance, Springer;Accademia Italiana di Economia Aziendale (AIDEA), vol. 28(2), pages 651-685, June.
    14. Jacob Elnaggar & Fern Tsien & Lucio Miele & Chindo Hicks & Clayton Yates & Melisa Davis, 2019. "An Integrative Genomics Approach for Associating Genetic Susceptibility with the Tumor Immune Microenvironment in Triple Negative Breast Cancer," Biomedical Journal of Scientific & Technical Research, Biomedical Research Network+, LLC, vol. 15(1), pages 1-12, February.
    15. Evans, Rhiannon & White, James & Turley, Ruth & Slater, Thomas & Morgan, Helen & Strange, Heather & Scourfield, Jonathan, 2017. "Comparison of suicidal ideation, suicide attempt and suicide in children and young people in care and non-care populations: Systematic review and meta-analysis of prevalence," Children and Youth Services Review, Elsevier, vol. 82(C), pages 122-129.
    16. Yi Ouyang & Ping-Chao Lee & Ling-Mei Ko, 2022. "A Systematic Review of the Development of Sport Policy Research (2000–2020)," Sustainability, MDPI, vol. 15(1), pages 1-22, December.
    17. Juliane Piasseschi de Bernardin Gonçalves & Giancarlo Lucchetti & Paulo Rossi Menezes & Homero Vallada, 2017. "Complementary religious and spiritual interventions in physical health and quality of life: A systematic review of randomized controlled clinical trials," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-21, October.
    18. Hang-Nga Mai & Jaeil Kim & Youn-Hee Choi & Du-Hyeong Lee, 2020. "Accuracy of Portable Face-Scanning Devices for Obtaining Three-Dimensional Face Models: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 18(1), pages 1-15, December.
    19. Federica Di Spirito & Alessandra Amato & Maria Pia Di Palo & Maria Contaldo & Francesco D’Ambrosio & Roberto Lo Giudice & Massimo Amato, 2022. "Oral Lesions Following Anti-SARS-CoV-2 Vaccination: A Systematic Review," IJERPH, MDPI, vol. 19(16), pages 1-18, August.
    20. Hyun Kim & Navneet Kaur Baidwan & David Kriebel & Manuel Cifuentes & Sherry Baron, 2018. "Asthma among World Trade Center First Responders: A Qualitative Synthesis and Bias Assessment," IJERPH, MDPI, vol. 15(6), pages 1-14, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0144538. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.