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Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis

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  • Bin Liang
  • Yang Guo
  • Yunhui Li
  • Hong Kong

Abstract

Background: A number of observational studies have been conducted to investigate the association of IL-10 gene polymorphisms with tuberculosis (TB) susceptibility. However, the results of different studies were inconsistent. The aim of this study was to investigate the relationship between IL-10 -1082G/A, -819T/C, and -592A/C polymorphisms and TB risk by meta-analysis. Methods: A literature search was conducted among six English databases (PubMed, Embase, Web of Science, Science Direct, SpringerLink and EBSCO) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases) to identify studies involving association between IL-10 −1082G/A, −819T/C, and −592A/C polymorphisms and TB susceptibility before May. 2013. Statistical analysis was performed using Revman 5.0 and Stata 12.0. Results: A total of 31 studies with 6,559 cases and 7,768 controls were included in this meta-analysis. The results showed that three polymorphisms (-1082G/A, -819T/C, and -592A/C) in the IL-10 gene were not associated with the risk of TB in general population. In the subgroup analysis by ethnicity, IL-10 -1082G/A polymorphism was associated with TB risk in Europeans (AA+AG vs. GG: OR = 0.57, 95% CI = 0. 0.37–0.89, P = 0.01) and Americans (AA+AG vs. GG: OR = 0.39, 95% CI = 0.27–0.57, P

Suggested Citation

  • Bin Liang & Yang Guo & Yunhui Li & Hong Kong, 2014. "Association between IL-10 Gene Polymorphisms and Susceptibility of Tuberculosis: Evidence Based on a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0088448
    DOI: 10.1371/journal.pone.0088448
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    Cited by:

    1. Xuan Gao & Junjun Chen & Zhongkai Tong & Guangdie Yang & Yinan Yao & Fei Xu & Jianying Zhou, 2015. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.

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