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Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis

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  • Myung-Han Hyun
  • Chung-Ho Lee
  • Min-Hyung Kang
  • Bong-Kyung Park
  • Young Ho Lee

Abstract

Objective: The aim of this study was to explore whether the interleukin (IL)-10 polymorphisms and their haplotypes contribute to asthma susceptibility. Methods: MEDLINE, EMBASE and the COCHRANE library databases were utilized to identify available articles. A meta-analysis was conducted on IL-10 -1082 G/A, -819 C/T, -592 C/A polymorphisms, and their haplotypes and asthma. Results: Eleven studies involving 2,215 asthma patients and 2,170 controls were considered in the meta-analysis. The meta-analysis revealed no association between asthma and the IL-10 -1082 G allele [Odds ratio (OR) = 0.87, 95% Confidence interval (CI) = 0.68–1.12, p = 0.28]. However, meta-analysis of the five studies in Hardy-Weinburg equilibrium produced the relationship between the IL-10 -1082 G allele and asthma (OR = 0.71, 95% CI = 0.60–0.83, p

Suggested Citation

  • Myung-Han Hyun & Chung-Ho Lee & Min-Hyung Kang & Bong-Kyung Park & Young Ho Lee, 2013. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Asthma: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-8, January.
    • Handle: RePEc:plo:pone00:0053758
    DOI: 10.1371/journal.pone.0053758
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    Cited by:

    1. Xuan Gao & Junjun Chen & Zhongkai Tong & Guangdie Yang & Yinan Yao & Fei Xu & Jianying Zhou, 2015. "Interleukin-10 Promoter Gene Polymorphisms and Susceptibility to Tuberculosis: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-16, June.
    2. Alexandra Noël & Sultan Yilmaz & Tori Farrow & Matthew Schexnayder & Oliver Eickelberg & Tomislav Jelesijevic, 2023. "Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to Asthma," IJERPH, MDPI, vol. 20(4), pages 1-20, February.

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