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The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis

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  • Jessica E Potts
  • Laura J Gray
  • Emer M Brady
  • Kamlesh Khunti
  • Melanie J Davies
  • Danielle H Bodicoat

Abstract

Aims: To determine the effects of glucagon-like peptide-1 receptor agonists compared with placebo and other anti-diabetic agents on weight loss in overweight or obese patients with type 2 diabetes mellitus. Methods: Electronic searches were conducted for randomised controlled trials that compared a glucagon-like peptide-1 receptor agonist therapy at a clinically relevant dose with a comparator treatment (other type 2 diabetes treatment or placebo) in adults with type 2 diabetes and a mean body mass index ≥ 25kg/m2. Pair-wise meta-analyses and mixed treatment comparisons were conducted to examine the difference in weight change at six months between the glucagon-like peptide-1 receptor agonists and each comparator. Results: In the mixed treatment comparison (27 trials), the glucagon-like peptide-1 receptor agonists were the most successful in terms of weight loss; exenatide 2mg/week: -1.62kg (95% CrI: -2.95kg, -0.30kg), exenatide 20μg: -1.37kg (95% CI: -222kg, -0.52kg), liraglutide 1.2mg: -1.01kg (95%CrI: -2.41kg, 0.38kg) and liraglutide 1.8mg: -1.51 kg (95% CI: -2.67kg, -0.37kg) compared with placebo. There were no differences between the GLP-1 receptor agonists in terms of weight loss. Conclusions: This review provides evidence that glucagon-like peptide-1 receptor agonist therapies are associated with weight loss in overweight or obese patients with type 2 diabetes with no difference in weight loss seen between the different types of GLP-1 receptor agonists assessed.

Suggested Citation

  • Jessica E Potts & Laura J Gray & Emer M Brady & Kamlesh Khunti & Melanie J Davies & Danielle H Bodicoat, 2015. "The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0126769
    DOI: 10.1371/journal.pone.0126769
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    References listed on IDEAS

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    1. Tom M. Palmer & Jaime L. Peters & Alex J. Sutton & Santiago G. Moreno, 2008. "Contour-enhanced funnel plots for meta-analysis," Stata Journal, StataCorp LP, vol. 8(2), pages 242-254, June.
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    1. Maria Mirabelli & Eusebio Chiefari & Patrizia Caroleo & Biagio Arcidiacono & Domenica Maria Corigliano & Stefania Giuliano & Francesco Saverio Brunetti & Sinan Tanyolaç & Daniela Patrizia Foti & Luigi, 2019. "Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes," IJERPH, MDPI, vol. 17(1), pages 1-11, December.

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