IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2019i1p207-d302583.html
   My bibliography  Save this article

Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes

Author

Listed:
  • Maria Mirabelli

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
    These authors contribute equally to this work.)

  • Eusebio Chiefari

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy
    These authors contribute equally to this work.)

  • Patrizia Caroleo

    (Complex Operative Structure Endocrinology-Diabetology, Hospital Pugliese-Ciaccio, 88100 Catanzaro, Italy)

  • Biagio Arcidiacono

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Domenica Maria Corigliano

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Stefania Giuliano

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Francesco Saverio Brunetti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Sinan Tanyolaç

    (Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, Biruni University, 34010 Istanbul, Turkey)

  • Daniela Patrizia Foti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

  • Luigi Puccio

    (Complex Operative Structure Endocrinology-Diabetology, Hospital Pugliese-Ciaccio, 88100 Catanzaro, Italy)

  • Antonio Brunetti

    (Department of Health Sciences, University “Magna Græcia” of Catanzaro, 88100 Catanzaro, Italy)

Abstract

Background : Liraglutide is the first glucagon-like peptide-1 receptor agonist (GLP-1 RA) based on the human GLP-1 sequence, with potential weight loss benefits, approved for the treatment of type 2 diabetes (T2D) mellitus. Herein, we aimed to assess the 5-year effectiveness of Liraglutide in the management of weight and glycometabolic control in a Southern Italian cohort of overweight/obese T2D patients, who were naïve to GLP-1 RAs. Patients and Methods : Forty overweight or obese patients treated with Liraglutide at doses up to 1.8 mg/day, in combination with one or more oral antidiabetic agents, were retrospectively assessed at baseline, during, and after 60 months of continuous therapy. Results : After 5 years of Liraglutide treatment, body weight decreased from 92.1 ± 20.5 kg to 87.3 ± 20.0 Kg ( p < 0.001), with a mean reduction of 5.0 ± 7.0 Kg and a body mass index (BMI) decrement of −2.0 ± 3.1 Kg/m 2 . On Spearman’s univariate analysis, change in body weight was correlated with female gender and baseline BMI. Hemoglobin A1c (HbA1c) decreased from 7.9 ± 0.9% at baseline to 7.0 ± 0.7% at the end of the study period ( p < 0.001), followed by a significant reduction in fasting plasma glucose. No significant differences emerged in other biochemical parameters, despite a trend toward improvement in lipid profile. Notwithstanding encouraging effects on several markers of cardiovascular disease (CVD), increments in the 5- and 10-year risk for the first atherosclerotic cardiovascular event were documented, as four incident cases of myocardial infarction. Conclusions : Prolonging treatment with Liraglutide can lead to durable benefits in relation to weight and glycemic control, with a greater impact on women. These results extend and corroborate previous observations, suggesting that gender per se may modulate the response to Liraglutide. Despite favorable effects on some established CVD risks factors, the long-term role of Liraglutide in primary prevention of CVD in patients with T2D remains controversial.

Suggested Citation

  • Maria Mirabelli & Eusebio Chiefari & Patrizia Caroleo & Biagio Arcidiacono & Domenica Maria Corigliano & Stefania Giuliano & Francesco Saverio Brunetti & Sinan Tanyolaç & Daniela Patrizia Foti & Luigi, 2019. "Long-Term Effectiveness of Liraglutide for Weight Management and Glycemic Control in Type 2 Diabetes," IJERPH, MDPI, vol. 17(1), pages 1-11, December.
    • Handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:207-:d:302583
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/1/207/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/1/207/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Jessica E Potts & Laura J Gray & Emer M Brady & Kamlesh Khunti & Melanie J Davies & Danielle H Bodicoat, 2015. "The Effect of Glucagon-Like Peptide 1 Receptor Agonists on Weight Loss in Type 2 Diabetes: A Systematic Review and Mixed Treatment Comparison Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-14, June.
    2. Tanya M. Teslovich & Kiran Musunuru & Albert V. Smith & Andrew C. Edmondson & Ioannis M. Stylianou & Masahiro Koseki & James P. Pirruccello & Samuli Ripatti & Daniel I. Chasman & Cristen J. Willer & C, 2010. "Biological, clinical and population relevance of 95 loci for blood lipids," Nature, Nature, vol. 466(7307), pages 707-713, August.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jordi Manuello & Joosung Min & Paul McCarthy & Fidel Alfaro-Almagro & Soojin Lee & Stephen Smith & Lloyd T. Elliott & Anderson M. Winkler & Gwenaëlle Douaud, 2024. "The effects of genetic and modifiable risk factors on brain regions vulnerable to ageing and disease," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Adrienne Tin & Pascal Schlosser & Pamela R. Matias-Garcia & Chris H. L. Thio & Roby Joehanes & Hongbo Liu & Zhi Yu & Antoine Weihs & Anselm Hoppmann & Franziska Grundner-Culemann & Josine L. Min & Vic, 2021. "Epigenome-wide association study of serum urate reveals insights into urate co-regulation and the SLC2A9 locus," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
    3. Sonali Pechlivanis & Susanne Moebus & Nils Lehmann & Raimund Erbel & Amir A Mahabadi & Per Hoffmann & Karl-Heinz Jöckel & Markus M Nöthen & Hagen S Bachmann & on behalf of the Heinz Nixdorf Recall Stu, 2020. "Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification—Results of the Heinz Nixdorf Recall study," PLOS ONE, Public Library of Science, vol. 15(5), pages 1-18, May.
    4. Linda Ottensmann & Rubina Tabassum & Sanni E. Ruotsalainen & Mathias J. Gerl & Christian Klose & Elisabeth Widén & Kai Simons & Samuli Ripatti & Matti Pirinen, 2023. "Genome-wide association analysis of plasma lipidome identifies 495 genetic associations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    5. Mathias I. Nielsen & Noortje Haan & Weston Kightlinger & Zilu Ye & Sally Dabelsteen & Minyan Li & Michael C. Jewett & Ieva Bagdonaite & Sergey Y. Vakhrushev & Hans H. Wandall, 2022. "Global mapping of GalNAc-T isoform-specificities and O-glycosylation site-occupancy in a tissue-forming human cell line," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    6. Peter H. Dixon & Adam P. Levine & Inês Cebola & Melanie M. Y. Chan & Aliya S. Amin & Anshul Aich & Monika Mozere & Hannah Maude & Alice L. Mitchell & Jun Zhang & Jenny Chambers & Argyro Syngelaki & Je, 2022. "GWAS meta-analysis of intrahepatic cholestasis of pregnancy implicates multiple hepatic genes and regulatory elements," Nature Communications, Nature, vol. 13(1), pages 1-18, December.
    7. Yang, Chiao-Yu & Lei, Lihua & Ho, Nhat & Fithian, William, 2022. "BONuS: Multiple Multivariate Testing with a Data-Adaptive Test Statistic," Research Papers 4031, Stanford University, Graduate School of Business.
    8. Jiacheng Miao & Hanmin Guo & Gefei Song & Zijie Zhao & Lin Hou & Qiongshi Lu, 2023. "Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    9. Yordi J. Vegte & Ruben N. Eppinga & M. Yldau Ende & Yanick P. Hagemeijer & Yuvaraj Mahendran & Elias Salfati & Albert V. Smith & Vanessa Y. Tan & Dan E. Arking & Ioanna Ntalla & Emil V. Appel & Claudi, 2023. "Genetic insights into resting heart rate and its role in cardiovascular disease," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    10. Reppell, M. & Zöllner, S., 2018. "An efficient algorithm for generating the internal branches of a Kingman coalescent," Theoretical Population Biology, Elsevier, vol. 122(C), pages 57-66.
    11. Mike Thompson & Mary Grace Gordon & Andrew Lu & Anchit Tandon & Eran Halperin & Alexander Gusev & Chun Jimmie Ye & Brunilda Balliu & Noah Zaitlen, 2022. "Multi-context genetic modeling of transcriptional regulation resolves novel disease loci," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    12. Xinyuan Zhang & Anastasia M. Lucas & Yogasudha Veturi & Theodore G. Drivas & William P. Bone & Anurag Verma & Wendy K. Chung & David Crosslin & Joshua C. Denny & Scott Hebbring & Gail P. Jarvik & Ifti, 2022. "Large-scale genomic analyses reveal insights into pleiotropy across circulatory system diseases and nervous system disorders," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2019:i:1:p:207-:d:302583. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.