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Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer’s Disease

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  • Zhuling Yu
  • Wei Li
  • Deren Hou
  • Lin Zhou
  • Yanyao Deng
  • Mi Tian
  • Xialu Feng

Abstract

In recent years, researchers have found that adiponectin (ANP) plays an important role in the pathogenesis of Alzheimer's disease (AD), and low serum concentrations of ANP are associated with AD. Higher plasma ANP level have a protective effect against the development of cognitive decline, suggesting that ANP may affect AD onset. Meanwhile, accumulating evidence supports the crucial role of ANP in the pathogenesis of AD. To study the relationship between ANP gene polymorphisms (rs266729, -11377C>G and rs1501299, G276T) and late-onset AD (LOAD), we carried out a case-control study that included 201 LOAD patients and 257 healthy control subjects. Statistically significant differences were detected in the genotype and allelotype frequency distributions of rs266729 and rs1501299 between the LOAD group and the control group, with a noticeable increase in the G and T allelotype frequency distributions in the LOAD group (P 0.05) between the LOAD group and control group, whereas the CG and GT haplotypes were significantly different (P

Suggested Citation

  • Zhuling Yu & Wei Li & Deren Hou & Lin Zhou & Yanyao Deng & Mi Tian & Xialu Feng, 2015. "Relationship between Adiponectin Gene Polymorphisms and Late-Onset Alzheimer’s Disease," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-11, April.
    • Handle: RePEc:plo:pone00:0125186
    DOI: 10.1371/journal.pone.0125186
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    1. David E. Reich & Michele Cargill & Stacey Bolk & James Ireland & Pardis C. Sabeti & Daniel J. Richter & Thomas Lavery & Rose Kouyoumjian & Shelli F. Farhadian & Ryk Ward & Eric S. Lander, 2001. "Linkage disequilibrium in the human genome," Nature, Nature, vol. 411(6834), pages 199-204, May.
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