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Interferon-Inducible Transmembrane Protein 3 Genetic Variant rs12252 and Influenza Susceptibility and Severity: A Meta-Analysis

Author

Listed:
  • Xianxian Yang
  • Bin Tan
  • Xipeng Zhou
  • Jian Xue
  • Xian Zhang
  • Peng Wang
  • Chuang Shao
  • Yingli Li
  • Chaorui Li
  • Huiming Xia
  • Jingfu Qiu

Abstract

Background: The pandemic influenza A (H1N1) pdm09 virus, avian influenza A (H5N1) virus, and influenza A (H7N9) virus induced severe morbidity and mortality throughout the world. Previous studies suggested a close association between the interferon-induced transmembrane protein-3 (IFITM3) genetic variant rs12252 and influenza. Here, we explored the correlation between the rs12252 and influenza susceptibility and severity using meta-analysis. Methods: Relevant studies published before May 22, 2014 were retrieved from PubMed, ISI web of knowledge, EBSCO, and Cochrane central register of controlled trials databases. Association between rs12252 and influenza susceptibility and severity were determined using statistical analysis of odds ratios (ORs). Results: A total of four studies consisting of 445 cases and 4180 controls were included in our analysis. Generally, there is increased risk of influenza in subjects carrying rs12252 in the recessive model (CC vs. CT+TT: OR = 2.35, 95% CI: 1.49-3.70, P

Suggested Citation

  • Xianxian Yang & Bin Tan & Xipeng Zhou & Jian Xue & Xian Zhang & Peng Wang & Chuang Shao & Yingli Li & Chaorui Li & Huiming Xia & Jingfu Qiu, 2015. "Interferon-Inducible Transmembrane Protein 3 Genetic Variant rs12252 and Influenza Susceptibility and Severity: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0124985
    DOI: 10.1371/journal.pone.0124985
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