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Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes

Author

Listed:
  • Lorena Ortega Moreno
  • Lucia Salvemini
  • Christine Mendonca
  • Massimiliano Copetti
  • Concetta De Bonis
  • Salvatore De Cosmo
  • Alessandro Doria
  • Vincenzo Trischitta
  • Claudia Menzaghi

Abstract

Background: High serum levels of the pro-inflammatory adipokine resistin have been associated with decreased renal function in the general population. The goal of this study was to investigate whether such association is also present among diabetic subjects, who are at increased risk of renal function loss. Methods: The cross-sectional association between serum resistin levels and estimated glomerular filtration rate (eGFR) was investigated in 1,560 type 2 diabetic (T2D) patients of European ancestry comprised in two different cohorts: 762 patients from San Giovanni Rotondo (SGR; Italy) and 798 patients from Boston (US). Results: Serum resistin was inversely associated with eGFR in SGR [β (SE) for one SD of resistin increment = -1.01 (0.70) ml/min/1.73m2, p = 0.019] and in Boston [β (SE) = -5.31 (0.74) ml/min/1.73m2, p

Suggested Citation

  • Lorena Ortega Moreno & Lucia Salvemini & Christine Mendonca & Massimiliano Copetti & Concetta De Bonis & Salvatore De Cosmo & Alessandro Doria & Vincenzo Trischitta & Claudia Menzaghi, 2015. "Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0119529
    DOI: 10.1371/journal.pone.0119529
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    References listed on IDEAS

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    1. Claire M. Steppan & Shannon T. Bailey & Savitha Bhat & Elizabeth J. Brown & Ronadip R. Banerjee & Christopher M. Wright & Hiralben R. Patel & Rexford S. Ahima & Mitchell A. Lazar, 2001. "The hormone resistin links obesity to diabetes," Nature, Nature, vol. 409(6818), pages 307-312, January.
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