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Positive Correlation of Serum Resistin Level with Peripheral Artery Disease in Patients with Chronic Kidney Disease Stage 3 to 5

Author

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  • Xin-Ning Ng

    (Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan)

  • Chi-Chong Tang

    (Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan)

  • Chih-Hsien Wang

    (Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
    School of Medicine, Tzu Chi University, Hualien 97004, Taiwan)

  • Jen-Pi Tsai

    (Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan
    School of Medicine, Tzu Chi University, Hualien 97004, Taiwan
    Division of Nephrology, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 62247, Taiwan)

  • Bang-Gee Hsu

    (Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien 97004, Taiwan
    School of Medicine, Tzu Chi University, Hualien 97004, Taiwan)

Abstract

Chronic kidney disease (CKD) is associated with higher risk of cardiovascular disease-related ischemic events, which includes peripheral arterial disease (PAD). PAD is a strong predictor of future cardiovascular events, which can cause significant morbidity and mortality. Resistin has been found to be involved in pathological processes leading to CVD. Therefore, we aim to investigate whether resistin level is correlated with PAD in patients with non-dialysis CKD stage 3 to 5. There were 240 CKD patients enrolled in this study. Ankle-brachial index (ABI) values were measured using the automated oscillometric method. An ABI value < 0.9 defined the low ABI group. Serum levels of human resistin were determined using a commercially available enzyme immunoassay. Thirty CKD patients (12.5%) were included in the low ABI group. Patients in the low ABI group were older and had higher resistin levels as well as higher diabetes mellitus, hypertension and habit of smoking, and lower estimated glomerular filtration rate than patients in the normal ABI group. After the adjustment for factors that were significantly associated with PAD by multivariate logistic regression analysis, age and serum resistin level were independent predictors of PAD. A high serum resistin level is an independent predictor of PAD in non-dialysis CKD stage 3 to 5.

Suggested Citation

  • Xin-Ning Ng & Chi-Chong Tang & Chih-Hsien Wang & Jen-Pi Tsai & Bang-Gee Hsu, 2021. "Positive Correlation of Serum Resistin Level with Peripheral Artery Disease in Patients with Chronic Kidney Disease Stage 3 to 5," IJERPH, MDPI, vol. 18(23), pages 1-8, December.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12746-:d:694120
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    References listed on IDEAS

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    1. Claire M. Steppan & Shannon T. Bailey & Savitha Bhat & Elizabeth J. Brown & Ronadip R. Banerjee & Christopher M. Wright & Hiralben R. Patel & Rexford S. Ahima & Mitchell A. Lazar, 2001. "The hormone resistin links obesity to diabetes," Nature, Nature, vol. 409(6818), pages 307-312, January.
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