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The hormone resistin links obesity to diabetes

Author

Listed:
  • Claire M. Steppan

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Shannon T. Bailey

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Savitha Bhat

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Elizabeth J. Brown

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Ronadip R. Banerjee

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Christopher M. Wright

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Hiralben R. Patel

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Rexford S. Ahima

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

  • Mitchell A. Lazar

    (Diabetes, and Metabolism, and The Penn Diabetes Center, University of Pennsylvania School of Medicine)

Abstract

Diabetes mellitus is a chronic disease that leads to complications including heart disease, stroke, kidney failure, blindness and nerve damage. Type 2 diabetes, characterized by target-tissue resistance to insulin, is epidemic in industrialized societies and is strongly associated with obesity; however, the mechanism by which increased adiposity causes insulin resistance is unclear. Here we show that adipocytes secrete a unique signalling molecule, which we have named resistin (for resistance to insulin). Circulating resistin levels are decreased by the anti-diabetic drug rosiglitazone, and increased in diet-induced and genetic forms of obesity. Administration of anti-resistin antibody improves blood sugar and insulin action in mice with diet-induced obesity. Moreover, treatment of normal mice with recombinant resistin impairs glucose tolerance and insulin action. Insulin-stimulated glucose uptake by adipocytes is enhanced by neutralization of resistin and is reduced by resistin treatment. Resistin is thus a hormone that potentially links obesity to diabetes.

Suggested Citation

  • Claire M. Steppan & Shannon T. Bailey & Savitha Bhat & Elizabeth J. Brown & Ronadip R. Banerjee & Christopher M. Wright & Hiralben R. Patel & Rexford S. Ahima & Mitchell A. Lazar, 2001. "The hormone resistin links obesity to diabetes," Nature, Nature, vol. 409(6818), pages 307-312, January.
    • Handle: RePEc:nat:nature:v:409:y:2001:i:6818:d:10.1038_35053000
    DOI: 10.1038/35053000
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    Cited by:

    1. Anna Czajkowska & Jadwiga Ambroszkiewicz & Anna Mróz & Katarzyna Witek & Dariusz Nowicki & Łukasz Małek, 2020. "The Effect of the Ultra-Marathon Run at a Distance of 100 Kilometers on the Concentration of Selected Adipokines in Adult Men," IJERPH, MDPI, vol. 17(12), pages 1-11, June.
    2. Tahereh Raeisi & Hossein Rezaie & Mina Darand & Akram Taheri & Nazila Garousi & Bahman Razi & Leonardo Roever & Reza Mohseni & Shimels Hussien Mohammed & Shahab Alizadeh, 2021. "Circulating resistin and follistatin levels in obese and non-obese women with polycystic ovary syndrome: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.
    3. Kinga Humińska-Lisowska & Jan Mieszkowski & Andrzej Kochanowicz & Aleksandra Bojarczuk & Bartłomiej Niespodziński & Paulina Brzezińska & Błażej Stankiewicz & Monika Michałowska-Sawczyn & Anna Grzywacz, 2022. "Implications of Adipose Tissue Content for Changes in Serum Levels of Exercise-Induced Adipokines: A Quasi-Experimental Study," IJERPH, MDPI, vol. 19(14), pages 1-17, July.
    4. Xin-Ning Ng & Chi-Chong Tang & Chih-Hsien Wang & Jen-Pi Tsai & Bang-Gee Hsu, 2021. "Positive Correlation of Serum Resistin Level with Peripheral Artery Disease in Patients with Chronic Kidney Disease Stage 3 to 5," IJERPH, MDPI, vol. 18(23), pages 1-8, December.
    5. Park, Hyun Joon & Francisco, Sara Chari & Pang, M. Rosemary & Peng, Lulu & Chi, Guangqing, 2023. "Exposure to anti-Black Lives Matter movement and obesity of the Black population," Social Science & Medicine, Elsevier, vol. 316(C).
    6. Wu, Hania Fei, 2021. "Social determination, health selection or indirect selection? Examining the causal directions between socioeconomic status and obesity in the Chinese adult population," Social Science & Medicine, Elsevier, vol. 269(C).
    7. Anna Lubkowska & Aleksandra Radecka & Iwona Bryczkowska & Iwona Rotter & Maria Laszczyńska & Wioleta Dudzińska, 2015. "Serum Adiponectin and Leptin Concentrations in Relation to Body Fat Distribution, Hematological Indices and Lipid Profile in Humans," IJERPH, MDPI, vol. 12(9), pages 1-21, September.
    8. Sameena Parveen & Yaser Ali Alhazmi, 2022. "Impact of Intermittent Fasting on Metabolic Syndrome and Periodontal Disease—A Suggested Preventive Strategy to Reduce the Public Health Burden," IJERPH, MDPI, vol. 19(21), pages 1-24, November.
    9. Lorena Ortega Moreno & Lucia Salvemini & Christine Mendonca & Massimiliano Copetti & Concetta De Bonis & Salvatore De Cosmo & Alessandro Doria & Vincenzo Trischitta & Claudia Menzaghi, 2015. "Serum Resistin and Glomerular Filtration Rate in Patients with Type 2 Diabetes," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-9, March.
    10. Wen Kong & Xun Niu & Tianshu Zeng & Meixia Lu & Lulu Chen, 2015. "Impact of Treatment with Metformin on Adipocytokines in Patients with Polycystic Ovary Syndrome: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(10), pages 1-20, October.

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