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Systematic Review on Irrational Use of Medicines in China and Vietnam

Author

Listed:
  • Wenhui Mao
  • Huyen Vu
  • Zening Xie
  • Wen Chen
  • Shenglan Tang

Abstract

Background: Irrational use of medicines has been an issue concerned all over the world and the outlooks in developing countries are more severe. This study aimed to assess the different patterns of irrational use of medicines and its influential factors in China and Vietnam. Methods: A systematic review was performed on both published and grey literatures in English, Chinese and Vietnamese languages between 1993 and 2013 based on the WHO framework. Quality assessment was conducted on the basis of the Critical Appraisal Skills Programme. Key indicators were analyzed to compare the irrational use of medicines in two countries. Results: A total of 67 published works about China and 29 about Vietnam were included, the majority of which were cross-sectional prescription studies in both China and Vietnam. Irrational use of medicines was found in both the countries but issues with polypharmacy as well as overuse of antibiotics were more severe in Vietnam while overuse of injections was unique to China. Various patterns of irrational use were also indicated between urban and rural areas, and among different levels of hospitals. Rarely does literature focus on the analysis of influential factors of irrational use of medicines. While lack of proper knowledge from both providers and patients were the most recognized influential factors in both countries, economic incentives from pharmaceutical companies in China, and weak control and regulation over prescriptions in Vietnam were the main factors attributed to this issue. Conclusion: Severe irrational use of medicines has been abundantly evidenced in both China and Vietnam, highlighting the importance of policy interventions on the issue. However, limited evidence on the appropriateness or its compliance (conformity) to guidelines of prescription has been found. In addition, convincing evidence on the underlying explanation of this issue is lacking, although economic incentives, health insurance coverage, and knowledge of service providers and users have been implied to be factors influencing irrational drug use.

Suggested Citation

  • Wenhui Mao & Huyen Vu & Zening Xie & Wen Chen & Shenglan Tang, 2015. "Systematic Review on Irrational Use of Medicines in China and Vietnam," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0117710
    DOI: 10.1371/journal.pone.0117710
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    References listed on IDEAS

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    Cited by:

    1. Yunzhen He & Guanshen Dou & Qiaoyun Huang & Xinyu Zhang & Yingfeng Ye & Mengcen Qian & Xiaohua Ying, 2018. "Does the leading pharmaceutical reform in China really solve the issue of overly expensive healthcare services? Evidence from an empirical study," PLOS ONE, Public Library of Science, vol. 13(1), pages 1-12, January.
    2. Wenhui Mao & Yunyu Huang & Wen Chen, 2019. "An analysis on rational use and affordability of medicine after the implementation of National Essential Medicines Policy and Zero Mark-up Policy in Hangzhou, China," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-13, March.
    3. Nguyen, Hong-Kong T. & Vuong, Quan-Hoang & Ho, Tung Manh & Vuong, Thu-Trang, 2018. "The “same bed, different dreams” of Vietnam and China: how (mis)trust could make or break it," OSF Preprints khtn5, Center for Open Science.
    4. Vu Quoc Dat & Phan Khanh Toan & H Rogier van Doorn & C Louise Thwaites & Behzad Nadjm, 2020. "Purchase and use of antimicrobials in the hospital sector of Vietnam, a lower middle-income country with an emerging pharmaceuticals market," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-17, October.
    5. Guan, Xiaodong & Tian, Ye & Song, Jiafang & Zhu, Dawei & Shi, Luwen, 2019. "Effect of physicians' knowledge on antibiotics rational use in China's county hospitals," Social Science & Medicine, Elsevier, vol. 224(C), pages 149-155.
    6. Chenxi Liu & Chaojie Liu & Dan Wang & Xinping Zhang, 2019. "Knowledge, Attitudes and Intentions to Prescribe Antibiotics: A Structural Equation Modeling Study of Primary Care Institutions in Hubei, China," IJERPH, MDPI, vol. 16(13), pages 1-16, July.
    7. Kanavos, Panos & Mills, Mackenzie & Zhang, Anwen, 2019. "Pharmaceutical policy in China," LSE Research Online Documents on Economics 108473, London School of Economics and Political Science, LSE Library.
    8. Xiaomin Wang & Leesa Lin & Ziming Xuan & Lu Li & Xudong Zhou, 2018. "Keeping Antibiotics at Home Promotes Self-Medication with Antibiotics among Chinese University Students," IJERPH, MDPI, vol. 15(4), pages 1-13, April.

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