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Evaluation of Uric Acid as a Prognostic Blood-Based Marker in a Large Cohort of Pancreatic Cancer Patients

Author

Listed:
  • Michael Stotz
  • Joanna Szkandera
  • Julia Seidel
  • Tatjana Stojakovic
  • Hellmut Samonigg
  • Daniel Reitz
  • Thomas Gary
  • Peter Kornprat
  • Renate Schaberl-Moser
  • Gerald Hoefler
  • Armin Gerger
  • Martin Pichler

Abstract

Background: Recently, chemical blood parameters gain more attraction as potential prognostic parameters in pancreatic cancer (PC). In the present study we investigated the prognostic relevance of the uric acid (UA) level in blood plasma at the time of diagnosis for overall survival (OS) in a large cohort of patients with PC. Patients and Methods: Data from 466 consecutive patients with ductal adenocarcinoma of the pancreas were evaluated retrospectively. Overall survival (OS) was analysed using the Kaplan-Meier method. To further evaluate the prognostic significance of the UA level, univariate and multivariate Cox regression models were calculated. Results: None of the clinicopathological parameters (tumour grade, clinical stage, age, CA19-9 level, Karnofski Index (KI) or surgical resection) except gender was associated with UA level. In univariate analysis we observed the elevated UA level (

Suggested Citation

  • Michael Stotz & Joanna Szkandera & Julia Seidel & Tatjana Stojakovic & Hellmut Samonigg & Daniel Reitz & Thomas Gary & Peter Kornprat & Renate Schaberl-Moser & Gerald Hoefler & Armin Gerger & Martin P, 2014. "Evaluation of Uric Acid as a Prognostic Blood-Based Marker in a Large Cohort of Pancreatic Cancer Patients," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-6, August.
    • Handle: RePEc:plo:pone00:0104730
    DOI: 10.1371/journal.pone.0104730
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    References listed on IDEAS

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    1. Yan Shi & James E. Evans & Kenneth L. Rock, 2003. "Molecular identification of a danger signal that alerts the immune system to dying cells," Nature, Nature, vol. 425(6957), pages 516-521, October.
    2. Joanna Szkandera & Michael Stotz & Florian Eisner & Gudrun Absenger & Tatjana Stojakovic & Hellmut Samonigg & Peter Kornprat & Renate Schaberl-Moser & Wael AlZoughbi & Anna Lena Ress & Friederike Soph, 2013. "External Validation of the Derived Neutrophil to Lymphocyte Ratio as a Prognostic Marker on a Large Cohort of Pancreatic Cancer Patients," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-5, November.
    3. Lisa M. Coussens & Zena Werb, 2002. "Inflammation and cancer," Nature, Nature, vol. 420(6917), pages 860-867, December.
    4. Alberto Mantovani & Paola Allavena & Antonio Sica & Frances Balkwill, 2008. "Cancer-related inflammation," Nature, Nature, vol. 454(7203), pages 436-444, July.
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