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Cancer-related inflammation

Author

Listed:
  • Alberto Mantovani

    (Istituto Clinico Humanitas IRCCS, Via Manzoni 56
    Istituto di Patologia Generale, Universita degli Studi di Milano)

  • Paola Allavena

    (Istituto Clinico Humanitas IRCCS, Via Manzoni 56)

  • Antonio Sica

    (Fondazione Humanitas per la Ricerca, Via Manzoni 56)

  • Frances Balkwill

    (Centre for Cancer & Inflammation, Institute of Cancer and the Cancer Research UK Clinical Centre, Barts and The London School of Medicine and Dentistry)

Abstract

The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that promotes the development of tumours. Regardless of its origin, 'smouldering' inflammation in the tumour microenvironment has many tumour-promoting effects. It aids in the proliferation and survival of malignant cells, promotes angiogenesis and metastasis, subverts adaptive immune responses, and alters responses to hormones and chemotherapeutic agents. The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.

Suggested Citation

  • Alberto Mantovani & Paola Allavena & Antonio Sica & Frances Balkwill, 2008. "Cancer-related inflammation," Nature, Nature, vol. 454(7203), pages 436-444, July.
    • Handle: RePEc:nat:nature:v:454:y:2008:i:7203:d:10.1038_nature07205
    DOI: 10.1038/nature07205
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    Cited by:

    1. Chern-Horng Lee & Sen-Yung Hsieh & Wen-Hung Huang & I-Kuan Wang & Tzung-Hai Yen, 2019. "Association between Ambient Particulate Matter 2.5 Exposure and Mortality in Patients with Hepatocellular Carcinoma," IJERPH, MDPI, vol. 16(14), pages 1-11, July.
    2. Vincent Grote & Matthias Frühwirth & Helmut K. Lackner & Nandu Goswami & Markus Köstenberger & Rudolf Likar & Maximilian Moser, 2021. "Cardiorespiratory Interaction and Autonomic Sleep Quality Improve during Sleep in Beds Made from Pinus cembra (Stone Pine) Solid Wood," IJERPH, MDPI, vol. 18(18), pages 1-20, September.
    3. repec:arp:sjmhsm:2022:p:9-17 is not listed on IDEAS
    4. M. Wozna & B. Kempisty & H. Piotrowska & J. Dorszewska & D. Bukowska & M. Nowicki, 2012. "The immunological, biochemical and molecular bases of canine senescence and carcinogenesis: a review," Veterinární medicína, Czech Academy of Agricultural Sciences, vol. 57(7), pages 350-359.
    5. Dong Wook Jekarl & Seungok Lee & Jung Hyun Kwon & Soon Woo Nam & Myungshin Kim & Yonggoo Kim & Jeong Won Jang, 2019. "Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-14, November.
    6. Tithi Biswas & Kylie H. Kang & Rohin Gawdi & David Bajor & Mitchell Machtay & Charu Jindal & Jimmy T. Efird, 2020. "Using the Systemic Immune-Inflammation Index (SII) as a Mid-Treatment Marker for Survival among Patients with Stage-III Locally Advanced Non-Small Cell Lung Cancer (NSCLC)," IJERPH, MDPI, vol. 17(21), pages 1-13, October.
    7. Sheng-Yin To & Li-Ting Kao & Jui-Hu Shih & I-Hsun Li & Tsai-Wang Huang & Chen-Liang Tsai & Chih-Feng Chian & Ching-Liang Ho & Ping-Ying Chang, 2022. "Modified-Dose Pembrolizumab and Prognostic Outcomes among Non-Small Cell Lung Cancer Patients: A Chart Review Study," IJERPH, MDPI, vol. 19(10), pages 1-13, May.

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