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Comparison of Efficacy and Safety of Tenofovir and Entecavir in Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis

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  • Weixia Ke
  • Li Liu
  • Chi Zhang
  • Xiaohua Ye
  • Yanhui Gao
  • Shudong Zhou
  • Yi Yang

Abstract

Objective: Tenofovir (TDF) and entecavir (ETV) are both potent antiviral agents for the treatment of chronic hepatitis B virus (HBV) infection. Multiple studies have compared efficacy and safety of these two agents, but yielded inconsistent results. Hence, we conducted a meta-analysis to discern comparative efficacy and safety. Methods: Published data relevant to a comparison of TDF and ETV used in HBV were included. HBV DNA suppression rate, ALT normalization rate, and HBeAg seroconversion rate at 24 weeks and 48 weeks were reviewed. Drug safety profiles and resistance were also discussed. Results: Seven articles met entry criteria. Four and six articles included data for 24 and 48-week HBV DNA suppression rates, respectively, and no significant differences for the rates between the two drugs were found in chronic HBV patients (TDF vs. ETV: relative risk [RR] = 1.10, 95% CI = 0.91–1.33 and RR = 1.07, 95% CI = 0.99–1.17 for 24 weeks and 48 weeks, respectively). For the ALT normalization rate (three studies for 24 weeks, four articles for 48 weeks) and HBeAg seroconversion rate (two and four studies for 24 weeks and 48 weeks, respectively), no difference was observed between TDF and ETV. Additionally, no significant distinction in short term safety was found for CHB patients. Conclusions: TDF and ETV are similarly effective and safe in chronic HBV patients after 24 weeks and 48 weeks of anti-viral therapy. Nevertheless, the long-term efficacy and safety of TDF and ETV should be monitored in prolonged therapy.

Suggested Citation

  • Weixia Ke & Li Liu & Chi Zhang & Xiaohua Ye & Yanhui Gao & Shudong Zhou & Yi Yang, 2014. "Comparison of Efficacy and Safety of Tenofovir and Entecavir in Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-8, June.
  • Handle: RePEc:plo:pone00:0098865
    DOI: 10.1371/journal.pone.0098865
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Eun Ju Cho & Jeong-Hoon Lee & Yuri Cho & Yun Bin Lee & Jeong-Ju Yoo & Minjong Lee & Dong Hyeon Lee & Su Jong Yu & Yoon Jun Kim & Jung-Hwan Yoon & Hyo-Suk Lee, 2015. "Comparison of the Efficacy of Entecavir and Tenofovir in Nucleos(T)ide Analogue-Experienced Chronic Hepatitis B Patients," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-10, June.
    2. Qiao-Ling Xie & Ying Zhu & Ling-Hong Wu & Lin-Lin Fu & Yan Xiang, 2015. "The Efficacy and Safety of Entecavir and Interferon Combination Therapy for Chronic Hepatitis B Virus Infection: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-19, July.
    3. Mehlika Toy & David W Hutton & Samuel K So, 2015. "Cost-Effectiveness and Cost Thresholds of Generic and Brand Drugs in a National Chronic Hepatitis B Treatment Program in China," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-19, November.

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