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Comparison of the Efficacy of Entecavir and Tenofovir in Nucleos(T)ide Analogue-Experienced Chronic Hepatitis B Patients

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  • Eun Ju Cho
  • Jeong-Hoon Lee
  • Yuri Cho
  • Yun Bin Lee
  • Jeong-Ju Yoo
  • Minjong Lee
  • Dong Hyeon Lee
  • Su Jong Yu
  • Yoon Jun Kim
  • Jung-Hwan Yoon
  • Hyo-Suk Lee

Abstract

The efficacy of entecavir (ETV) and tenofovir (TDF) for the treatment of nucleos(t)ide analogue (NA)-experienced chronic hepatitis B (CHB) patients has been little studied. Here, we compare the efficacy of both ETV and TDF in NA-experienced CHB patients without detectable genotypic resistance. This retrospective cohort study included consecutive NA-experienced patients who had neither current nor previous genotypic resistance and had received ETV or TDF for at least 6 months. Overall, 202 patients (146 patients in the ETV group and 56 in the TDF group) were analyzed. The cumulative probabilities of complete virologic suppression (CVS) at month 12 were 76.1% in the ETV group and 95.0% in the TDF group (P

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  • Eun Ju Cho & Jeong-Hoon Lee & Yuri Cho & Yun Bin Lee & Jeong-Ju Yoo & Minjong Lee & Dong Hyeon Lee & Su Jong Yu & Yoon Jun Kim & Jung-Hwan Yoon & Hyo-Suk Lee, 2015. "Comparison of the Efficacy of Entecavir and Tenofovir in Nucleos(T)ide Analogue-Experienced Chronic Hepatitis B Patients," PLOS ONE, Public Library of Science, vol. 10(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0130392
    DOI: 10.1371/journal.pone.0130392
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    References listed on IDEAS

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    1. Georg Heinze & Michael Schemper, 2001. "A Solution to the Problem of Monotone Likelihood in Cox Regression," Biometrics, The International Biometric Society, vol. 57(1), pages 114-119, March.
    2. Weixia Ke & Li Liu & Chi Zhang & Xiaohua Ye & Yanhui Gao & Shudong Zhou & Yi Yang, 2014. "Comparison of Efficacy and Safety of Tenofovir and Entecavir in Chronic Hepatitis B Virus Infection: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-8, June.
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