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Patient Self-Management of Oral Anticoagulation with Vitamin K Antagonists in Everyday Practice: Efficacy and Safety in a Nationwide Long-Term Prospective Cohort Study

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  • Michael Nagler
  • Lucas M Bachmann
  • Pirmin Schmid
  • Pascale Raddatz Müller
  • Walter A Wuillemin

Abstract

Patient self-management (PSM) of oral anticoagulation is under discussion, because evidence from real-life settings is missing. Using data from a nationwide, prospective cohort study in Switzerland, we assessed overall long-term efficacy and safety of PSM and examined subgroups. Data of 1140 patients (5818.9 patient-years) were analysed and no patient were lost to follow-up. Median follow-up was 4.3 years (range 0.2–12.8 years). Median age at the time of training was 54.2 years (range 18.2–85.2) and 34.6% were women. All-cause mortality was 1.4 per 100 patient-years (95% CI 1.1–1.7) with a higher rate in patients with atrial fibrillation (2.5; 1.6–3.7; p 50 years of age (2.0; 1.6–2.6; p

Suggested Citation

  • Michael Nagler & Lucas M Bachmann & Pirmin Schmid & Pascale Raddatz Müller & Walter A Wuillemin, 2014. "Patient Self-Management of Oral Anticoagulation with Vitamin K Antagonists in Everyday Practice: Efficacy and Safety in a Nationwide Long-Term Prospective Cohort Study," PLOS ONE, Public Library of Science, vol. 9(4), pages 1-9, April.
    • Handle: RePEc:plo:pone00:0095761
    DOI: 10.1371/journal.pone.0095761
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    References listed on IDEAS

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    1. Tsang, Eric W. K., 2014. "Old and New," Management and Organization Review, Cambridge University Press, vol. 10(03), pages 390-390, November.
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    1. Sabine Michelsen Raunbak & Anne Sig Sørensen & Louise Hansen & Flemming Skjøth & Torben Bjerregaard Larsen & Lars Holger Ehlers, 2022. "Cost Effectiveness of Patient Self-Managed Warfarin Compared with Direct Oral Anticoagulants in Atrial Fibrillation: An Economic Evaluation in a Danish Healthcare Sector Setting," PharmacoEconomics - Open, Springer, vol. 6(4), pages 483-494, July.

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