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Carbon Dioxide and Fruit Odor Transduction in Drosophila Olfactory Neurons. What Controls their Dynamic Properties?

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  • Andrew S French
  • Shannon Meisner
  • Chih-Ying Su
  • Päivi H Torkkeli

Abstract

We measured frequency response functions between odorants and action potentials in two types of neurons in Drosophila antennal basiconic sensilla. CO2 was used to stimulate ab1C neurons, and the fruit odor ethyl butyrate was used to stimulate ab3A neurons. We also measured frequency response functions for light-induced action potential responses from transgenic flies expressing H134R-channelrhodopsin-2 (ChR2) in the ab1C and ab3A neurons. Frequency response functions for all stimulation methods were well-fitted by a band-pass filter function with two time constants that determined the lower and upper frequency limits of the response. Low frequency time constants were the same in each type of neuron, independent of stimulus method, but varied between neuron types. High frequency time constants were significantly slower with ethyl butyrate stimulation than light or CO2 stimulation. In spite of these quantitative differences, there were strong similarities in the form and frequency ranges of all responses. Since light-activated ChR2 depolarizes neurons directly, rather than through a chemoreceptor mechanism, these data suggest that low frequency dynamic properties of Drosophila olfactory sensilla are dominated by neuron-specific ionic processes during action potential production. In contrast, high frequency dynamics are limited by processes associated with earlier steps in odor transduction, and CO2 is detected more rapidly than fruit odor.

Suggested Citation

  • Andrew S French & Shannon Meisner & Chih-Ying Su & Päivi H Torkkeli, 2014. "Carbon Dioxide and Fruit Odor Transduction in Drosophila Olfactory Neurons. What Controls their Dynamic Properties?," PLOS ONE, Public Library of Science, vol. 9(1), pages 1-8, January.
  • Handle: RePEc:plo:pone00:0086347
    DOI: 10.1371/journal.pone.0086347
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    References listed on IDEAS

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    1. Chih-Ying Su & Karen Menuz & Johannes Reisert & John R. Carlson, 2012. "Non-synaptic inhibition between grouped neurons in an olfactory circuit," Nature, Nature, vol. 492(7427), pages 66-71, December.
    2. Minrong Ai & Soohong Min & Yael Grosjean & Charlotte Leblanc & Rati Bell & Richard Benton & Greg S. B. Suh, 2010. "Acid sensing by the Drosophila olfactory system," Nature, Nature, vol. 468(7324), pages 691-695, December.
    3. Walton D. Jones & Pelin Cayirlioglu & Ilona Grunwald Kadow & Leslie B. Vosshall, 2007. "Two chemosensory receptors together mediate carbon dioxide detection in Drosophila," Nature, Nature, vol. 445(7123), pages 86-90, January.
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