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Acid sensing by the Drosophila olfactory system

Author

Listed:
  • Minrong Ai

    (Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University, School of Medicine)

  • Soohong Min

    (Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University, School of Medicine)

  • Yael Grosjean

    (Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne
    Present addresses: Centre des Sciences du Goût et de l’Alimentation, UMR-6265 CNRS, UMR-1324 INRA, Université de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France (Y.G.); Université Paris Diderot – Paris 7, 16 rue Marguerite Duras, 75013 Paris, France (C.L.).)

  • Charlotte Leblanc

    (Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University, School of Medicine
    Present addresses: Centre des Sciences du Goût et de l’Alimentation, UMR-6265 CNRS, UMR-1324 INRA, Université de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, France (Y.G.); Université Paris Diderot – Paris 7, 16 rue Marguerite Duras, 75013 Paris, France (C.L.).)

  • Rati Bell

    (Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne)

  • Richard Benton

    (Center for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne)

  • Greg S. B. Suh

    (Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University, School of Medicine)

Abstract

Sensing the odour of acid We are familiar with the unpleasant and often irritating odour associated with acids, but whereas acid receptors are known to underlie the detection of sour tastes, no acid-sensing neurons were known in the olfactory system. Greg Suh and colleagues now report the identification of such neurons in the olfactory system of the fruitfly, Drosophila melanogaster. Acid sensing also requires the transmembrane protein IR64a to be expressed in those neurons. IR64a is not sufficient by itself to determine acid recognition, but its requirement is the first known function for a member of the recently discovered ionotropic receptor family of putative odorant receptors.

Suggested Citation

  • Minrong Ai & Soohong Min & Yael Grosjean & Charlotte Leblanc & Rati Bell & Richard Benton & Greg S. B. Suh, 2010. "Acid sensing by the Drosophila olfactory system," Nature, Nature, vol. 468(7324), pages 691-695, December.
    • Handle: RePEc:nat:nature:v:468:y:2010:i:7324:d:10.1038_nature09537
    DOI: 10.1038/nature09537
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    Cited by:

    1. Thomas A. Verschut & Renny Ng & Nicolas P. Doubovetzky & Guillaume Calvez & Jan L. Sneep & Adriaan J. Minnaard & Chih-Ying Su & Mikael A. Carlsson & Bregje Wertheim & Jean-Christophe Billeter, 2023. "Aggregation pheromones have a non-linear effect on oviposition behavior in Drosophila melanogaster," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Raquel Álvarez-Ocaña & Michael P. Shahandeh & Vijayaditya Ray & Thomas O. Auer & Nicolas Gompel & Richard Benton, 2023. "Odor-regulated oviposition behavior in an ecological specialist," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Liangyu Tao & Samuel P. Wechsler & Vikas Bhandawat, 2023. "Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila," Nature Communications, Nature, vol. 14(1), pages 1-22, December.
    4. Javier J How & Saket Navlakha & Sreekanth H Chalasani, 2021. "Neural network features distinguish chemosensory stimuli in Caenorhabditis elegans," PLOS Computational Biology, Public Library of Science, vol. 17(11), pages 1-38, November.
    5. J Roman Arguello & Carolina Sellanes & Yann Ru Lou & Robert A Raguso, 2013. "Can Yeast (S. cerevisiae) Metabolic Volatiles Provide Polymorphic Signaling?," PLOS ONE, Public Library of Science, vol. 8(8), pages 1-12, August.

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