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Autophagic Protein Beclin 1 Serves as an Independent Positive Prognostic Biomarker for Non-Small Cell Lung Cancer

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Listed:
  • Weihua Zhou
  • Caifeng Yue
  • Jinyun Deng
  • Ronghuan Hu
  • Jie Xu
  • Long Feng
  • Qiongyu Lan
  • Wenfeng Zhang
  • Dexiang Ji
  • Jianbing Wu
  • Quentin Liu
  • Anwen Liu

Abstract

Beclin 1, a key regulator of autophagy, has been found to be aberrantly expressed in a variety of human malignancies. Herein, we employed immunohistochemistry (IHC) to detect the protein expression of Beclin 1 in non-small cell lung cancer (NSCLC) and paired normal adjacent lung tissues, and analyzed its clinicopathological/prognostic significance in NSCLC. Receiver operating characteristic (ROC) curve analysis was utilized to determine a cutoff point (>2 VS. ≤2) for Beclin 1 expression in a training set (n = 105). For validation, the ROC-derived cutoff value was subjected to analysis of the association of Beclin 1 with patients’ clinical characteristics and outcome in a testing set (n = 111) and the overall patient cohort (n = 216). Our data showed that Beclin 1 was significantly lower in NSCLC tissues compared with the adjacent normal tissues, negatively associating with tumor recurrence rate (65.8% VS 32.3%; p

Suggested Citation

  • Weihua Zhou & Caifeng Yue & Jinyun Deng & Ronghuan Hu & Jie Xu & Long Feng & Qiongyu Lan & Wenfeng Zhang & Dexiang Ji & Jianbing Wu & Quentin Liu & Anwen Liu, 2013. "Autophagic Protein Beclin 1 Serves as an Independent Positive Prognostic Biomarker for Non-Small Cell Lung Cancer," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-1, November.
    • Handle: RePEc:plo:pone00:0080338
    DOI: 10.1371/journal.pone.0080338
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    References listed on IDEAS

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    1. Zhang Lou-Qian & Yin Rong & Li Ming & Yang Xin & Jiang Feng & Xu Lin, 2013. "The Prognostic Value of Epigenetic Silencing of p16 Gene in NSCLC Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
    2. Noboru Mizushima & Beth Levine & Ana Maria Cuervo & Daniel J. Klionsky, 2008. "Autophagy fights disease through cellular self-digestion," Nature, Nature, vol. 451(7182), pages 1069-1075, February.
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