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Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis

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  • Hanyu Cao
  • Si Wang
  • Zhenyu Zhang
  • Jiangyan Lou

Abstract

Objective: This study aimed to examine the prognostic value of overexpressed p16INK4a in vulvar cancer. Although the tumor suppressor p16INK4a has been shown to be of prognostic value in a wide variety of cancers and precancerous lesions, its role in the vulvar cancer is still unclear. Methods: All publications in English language on the association between p16INK4a and clinicopathological features of vulvar cancer were searched from Pubmed, Embase, and Web of Science, and those in Chinese language were identified manually and online from the China National Knowledge Infrastructure. Strict inclusion and exclusion criteria were followed. Odds ratios(ORs) or risk ratios(RRs) with 95% confidence intervals(CIs) were pooled to assess the strength of association. Publication bias was estimated using funnel plots and the Egger’s regression test. Results: A total of 17 studies with 2309 patients were included. The p16INK4a overexpression was found to correlate significantly with the lower International Federation of Gynecology and Obstetrics stage(I+II vs III+IV; OR = 0.60,95%CI:0.41–0.86,P = 0.006),negative lymph node metastasis(negative vs positive; OR = 0.61,95%CI:0.39–0.95,P = 0.029),patient’s age

Suggested Citation

  • Hanyu Cao & Si Wang & Zhenyu Zhang & Jiangyan Lou, 2016. "Prognostic Value of Overexpressed p16INK4a in Vulvar Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0152459
    DOI: 10.1371/journal.pone.0152459
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    References listed on IDEAS

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    1. Zhang Lou-Qian & Yin Rong & Li Ming & Yang Xin & Jiang Feng & Xu Lin, 2013. "The Prognostic Value of Epigenetic Silencing of p16 Gene in NSCLC Patients: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(1), pages 1-7, January.
    2. Jiaying Lin & Andreas E Albers & Jinbao Qin & Andreas M Kaufmann, 2014. "Prognostic Significance of Overexpressed p16INK4a in Patients with Cervical Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 9(9), pages 1-7, September.
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