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Autophagy fights disease through cellular self-digestion

Author

Listed:
  • Noboru Mizushima

    (Tokyo Medical and Dental University)

  • Beth Levine

    (University of Texas Southwestern Medical Center)

  • Ana Maria Cuervo

    (Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA)

  • Daniel J. Klionsky

    (Cellular and Developmental Biology and Biological Chemistry, University of Michigan)

Abstract

Garbage in, all sorts out Until recently, autophagy, or cellular self-digestion, was thought of primarily as part of the cell's garbage disposal system. Now it is know to be involved in cellular protein and organelle degradation during development as well as during adaptations to changing environmental conditions. Many intriguing questions remain to be answered about this process. For example, how can this one pathway be involved in cytoprotection as well as cell death? What is the connection between autophagy and human disease or ageing? In a review, Mizushima et al. consider recent progress in the field.

Suggested Citation

  • Noboru Mizushima & Beth Levine & Ana Maria Cuervo & Daniel J. Klionsky, 2008. "Autophagy fights disease through cellular self-digestion," Nature, Nature, vol. 451(7182), pages 1069-1075, February.
    • Handle: RePEc:nat:nature:v:451:y:2008:i:7182:d:10.1038_nature06639
    DOI: 10.1038/nature06639
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    Cited by:

    1. Barbara Baldo & Rana Soylu & Åsa Petersén, 2013. "Maintenance of Basal Levels of Autophagy in Huntington’s Disease Mouse Models Displaying Metabolic Dysfunction," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-15, December.
    2. Ao Bian & Mingjun Shi & Brianna Flores & Nancy Gillings & Peng Li & Shirley Xiao Yan & Beth Levine & Changying Xing & Ming Chang Hu, 2017. "Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice," PLOS ONE, Public Library of Science, vol. 12(9), pages 1-21, September.

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