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Total Blood Mercury Levels and Depression among Adults in the United States: National Health and Nutrition Examination Survey 2005–2008

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  • Tsz Hin H Ng
  • Jana M Mossey
  • Brian K Lee

Abstract

Background: Mercury is a neurotoxicant linked with psychiatric symptoms at high levels of exposure. However, it is unclear whether an association is present at the low exposure levels in the US adult population. Materials and Methods: Cross-sectional associations of total blood mercury and depression were assessed in 6,911 adults age ≥20 in the National Health and Nutrition Examination Survey (NHANES), 2005–2008. The Patient Health Questionnaire-9 was used to assess depression (high likelihood of a depressive spectrum disorder diagnosis; score 5–27). Results: Unadjusted survey weighted logistic regression suggested that higher total blood mercury was associated with lower odds of depression (Odds Ratio = 0.49, 95% Confidence Interval: 0.36–0.65, comparing the highest and lowest mercury quintiles). This association largely disappeared after adjustment for sociodemographic variables (income-poverty ratio, education, marital status). However, in age-stratified analyses, this inverse relationship remained in older adults (age ≥40) even after adjustment for sociodemographic variables. Simulation analyses adjusting for expected confounding effects of fish intake suggested that the inverse relationship among older adults may be plausibly attributed to residual confounding (Odds Ratio = 0.75, 95% Confidence Interval: 0.50–1.12, comparing the highest and lowest mercury quintiles). Conclusions: Higher total blood mercury was not associated with increased odds of depression. The lower odds of depression in older adults with higher total blood mercury may be due to residual confounding.

Suggested Citation

  • Tsz Hin H Ng & Jana M Mossey & Brian K Lee, 2013. "Total Blood Mercury Levels and Depression among Adults in the United States: National Health and Nutrition Examination Survey 2005–2008," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0079339
    DOI: 10.1371/journal.pone.0079339
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    References listed on IDEAS

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    1. Nga L. Tran & Leila Barraj & Kim Smith & Annabelle Javier & Thomas A. Burke, 2004. "Combining Food Frequency and Survey Data to Quantify Long‐Term Dietary Exposure: A Methyl Mercury Case Study," Risk Analysis, John Wiley & Sons, vol. 24(1), pages 19-30, February.
    2. Agnès Le Port & Alice Gueguen & Emmanuelle Kesse-Guyot & Maria Melchior & Cédric Lemogne & Hermann Nabi & Marcel Goldberg & Marie Zins & Sébastien Czernichow, 2012. "Association between Dietary Patterns and Depressive Symptoms Over Time: A 10-Year Follow-Up Study of the GAZEL Cohort," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-8, December.
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