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A Genetic Polymorphism in pre-miR-27a Confers Clinical Outcome of Non-Small Cell Lung Cancer in a Chinese Population

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Listed:
  • Jiali Xu
  • Zhiqiang Yin
  • Hong Shen
  • Wen Gao
  • Yingying Qian
  • Dong Pei
  • Lingxiang Liu
  • Yongqian Shu

Abstract

Background: Recent evidence indicates that microRNAs (miRNAs) can function as tumor suppressors and oncogenes. Single nucleotide polymorphisms (SNPs) at miRNA genes can influence the maturation of miRNAs or miRNA-mediated transcriptional regulation. Our objective was to investigate the association of SNPs in deregulated miRNAs with clinical outcome in patients with non-small cell lung cancer (NSCLC) in a Chinese population. Methods: Deregulated miRNAs in NSCLC and their SNPs were identified through public databases. A single SNP, rs895819 in pre-miR-27a, was found suitable for selection. TaqMan assays were performed for genotyping and to assess the effect on the overall survival (OS) and chemotherapy response in 576 NSCLC patients. Results: Log-rank test and Cox regression analysis indicated that the G allele of rs895819 was associated with shorter survival and increased risk of death in NSCLC [dominant model: 22.0 vs. 46.0 months, P

Suggested Citation

  • Jiali Xu & Zhiqiang Yin & Hong Shen & Wen Gao & Yingying Qian & Dong Pei & Lingxiang Liu & Yongqian Shu, 2013. "A Genetic Polymorphism in pre-miR-27a Confers Clinical Outcome of Non-Small Cell Lung Cancer in a Chinese Population," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    • Handle: RePEc:plo:pone00:0079135
    DOI: 10.1371/journal.pone.0079135
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    1. Victor Ambros, 2004. "The functions of animal microRNAs," Nature, Nature, vol. 431(7006), pages 350-355, September.
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