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Patterning in Placental 11-B Hydroxysteroid Dehydrogenase Methylation According to Prenatal Socioeconomic Adversity

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  • Allison A Appleton
  • David A Armstrong
  • Corina Lesseur
  • Joyce Lee
  • James F Padbury
  • Barry M Lester
  • Carmen J Marsit

Abstract

Background: Prenatal socioeconomic adversity as an intrauterine exposure is associated with a range of perinatal outcomes although the explanatory mechanisms are not well understood. The development of the fetus can be shaped by the intrauterine environment through alterations in the function of the placenta. In the placenta, the HSD11B2 gene encodes the 11-beta hydroxysteroid dehydrogenase enzyme, which is responsible for the inactivation of maternal cortisol thereby protecting the developing fetus from this exposure. This gene is regulated by DNA methylation, and this methylation and the expression it controls has been shown to be susceptible to a variety of stressors from the maternal environment. The association of prenatal socioeconomic adversity and placental HSD11B2 methylation has not been examined. Following a developmental origins of disease framework, prenatal socioeconomic adversity may alter fetal response to the postnatal environment through functional epigenetic alterations in the placenta. Therefore, we hypothesized that prenatal socioeconomic adversity would be associated with less HSD11B2 methylation. Methods and Findings: We examined the association between DNA methylation of the HSD11B2 promoter region in the placenta of 444 healthy term newborn infants and several markers of prenatal socioeconomic adversity: maternal education, poverty, dwelling crowding, tobacco use and cumulative risk. We also examined whether such associations were sex-specific. We found that infants whose mothers experienced the greatest levels of socioeconomic adversity during pregnancy had the lowest extent of placental HSD11B2 methylation, particularly for males. Associations were maintained for maternal education when adjusting for confounders (p

Suggested Citation

  • Allison A Appleton & David A Armstrong & Corina Lesseur & Joyce Lee & James F Padbury & Barry M Lester & Carmen J Marsit, 2013. "Patterning in Placental 11-B Hydroxysteroid Dehydrogenase Methylation According to Prenatal Socioeconomic Adversity," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-7, September.
  • Handle: RePEc:plo:pone00:0074691
    DOI: 10.1371/journal.pone.0074691
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    References listed on IDEAS

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    1. Power, C. & Hyppönen, E. & Smith, G.D., 2005. "Socioeconomic position in childhood and early adult life and risk of mortality: A prospective study of the mothers of the 1958 British birth cohort," American Journal of Public Health, American Public Health Association, vol. 95(8), pages 1396-1402.
    2. Case, Anne & Fertig, Angela & Paxson, Christina, 2005. "The lasting impact of childhood health and circumstance," Journal of Health Economics, Elsevier, vol. 24(2), pages 365-389, March.
    3. Gerrit van den Berg & Manon van Eijsden & Tanja G M Vrijkotte & Reinoud J B J Gemke, 2012. "Educational Inequalities in Perinatal Outcomes: The Mediating Effect of Smoking and Environmental Tobacco Exposure," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-6, May.
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    1. Aurélie Nakamura & Olivier François & Johanna Lepeule, 2021. "Epigenetic Alterations of Maternal Tobacco Smoking during Pregnancy: A Narrative Review," IJERPH, MDPI, vol. 18(10), pages 1-19, May.

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