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Genome-Wide Meta-Analysis of Systolic Blood Pressure in Children with Sickle Cell Disease

Author

Listed:
  • Pallav Bhatnagar
  • Emily Barron-Casella
  • Christopher J Bean
  • Jacqueline N Milton
  • Clinton T Baldwin
  • Martin H Steinberg
  • Michael DeBaun
  • James F Casella
  • Dan E Arking

Abstract

In pediatric sickle cell disease (SCD) patients, it has been reported that higher systolic blood pressure (SBP) is associated with increased risk of a silent cerebral infarction (SCI). SCI is a major cause of neurologic morbidity in children with SCD, and blood pressure is a potential modulator of clinical manifestations of SCD; however, the risk factors underlying these complications are not well characterized. The aim of this study was to identify genetic variants that influence SBP in an African American population in the setting of SCD, and explore the use of SBP as an endo-phenotype for SCI. We conducted a genome-wide meta-analysis for SBP using two SCD cohorts, as well as a candidate screen based on published SBP loci. A total of 1,617 patients were analyzed, and while no SNP reached genome-wide significance (P-value

Suggested Citation

  • Pallav Bhatnagar & Emily Barron-Casella & Christopher J Bean & Jacqueline N Milton & Clinton T Baldwin & Martin H Steinberg & Michael DeBaun & James F Casella & Dan E Arking, 2013. "Genome-Wide Meta-Analysis of Systolic Blood Pressure in Children with Sickle Cell Disease," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    • Handle: RePEc:plo:pone00:0074193
    DOI: 10.1371/journal.pone.0074193
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    References listed on IDEAS

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