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Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies

Author

Listed:
  • Ilja M Nolte
  • Chris Wallace
  • Stephen J Newhouse
  • Daryl Waggott
  • Jingyuan Fu
  • Nicole Soranzo
  • Rhian Gwilliam
  • Panos Deloukas
  • Irina Savelieva
  • Dongling Zheng
  • Chrysoula Dalageorgou
  • Martin Farrall
  • Nilesh J Samani
  • John Connell
  • Morris Brown
  • Anna Dominiczak
  • Mark Lathrop
  • Eleftheria Zeggini
  • Louise V Wain
  • for the The Wellcome Trust Case Control Consortium
  • The DCCT/EDIC Research Group
  • Christopher Newton-Cheh
  • Mark Eijgelsheim
  • Kenneth Rice
  • Paul I W de Bakker
  • for the QTGEN consortium
  • Arne Pfeufer
  • Serena Sanna
  • Dan E Arking
  • for the QTSCD consortium
  • Folkert W Asselbergs
  • Tim D Spector
  • Nicholas D Carter
  • Steve Jeffery
  • Martin Tobin
  • Mark Caulfield
  • Harold Snieder
  • Andrew D Paterson
  • Patricia B Munroe
  • Yalda Jamshidi

Abstract

To identify loci affecting the electrocardiographic QT interval, a measure of cardiac repolarisation associated with risk of ventricular arrhythmias and sudden cardiac death, we conducted a meta-analysis of three genome-wide association studies (GWAS) including 3,558 subjects from the TwinsUK and BRIGHT cohorts in the UK and the DCCT/EDIC cohort from North America. Five loci were significantly associated with QT interval at P

Suggested Citation

  • Ilja M Nolte & Chris Wallace & Stephen J Newhouse & Daryl Waggott & Jingyuan Fu & Nicole Soranzo & Rhian Gwilliam & Panos Deloukas & Irina Savelieva & Dongling Zheng & Chrysoula Dalageorgou & Martin F, 2009. "Common Genetic Variation Near the Phospholamban Gene Is Associated with Cardiac Repolarisation: Meta-Analysis of Three Genome-Wide Association Studies," PLOS ONE, Public Library of Science, vol. 4(7), pages 1-10, July.
    • Handle: RePEc:plo:pone00:0006138
    DOI: 10.1371/journal.pone.0006138
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    References listed on IDEAS

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    1. Nick Patterson & Alkes L Price & David Reich, 2006. "Population Structure and Eigenanalysis," PLOS Genetics, Public Library of Science, vol. 2(12), pages 1-20, December.
    2. White, Halbert, 1982. "Maximum Likelihood Estimation of Misspecified Models," Econometrica, Econometric Society, vol. 50(1), pages 1-25, January.
    3. B. Devlin & Kathryn Roeder, 1999. "Genomic Control for Association Studies," Biometrics, The International Biometric Society, vol. 55(4), pages 997-1004, December.
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    1. Arend Voorman & Thomas Lumley & Barbara McKnight & Kenneth Rice, 2011. "Behavior of QQ-Plots and Genomic Control in Studies of Gene-Environment Interaction," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-7, May.

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