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Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk

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  • Haoran Wang
  • Lei Liu
  • Jinzhao Zhao
  • Guanglin Cui
  • Chen Chen
  • Hu Ding
  • Dao Wen Wang

Abstract

Background: The evidence that the variants GCK rs1799884, GCKR rs780094, MTNR1B rs10830963 and G6PC2 rs560887, which are related to fasting plasma glucose levels, increase the risk of type 2 diabetes mellitus (T2DM) is contradictory. We therefore performed a meta-analysis to derive a more precise estimation of the association between these polymorphisms and T2DM. Methods: All the publications examining the associations of these variants with risk of T2DM were retrieved from the MEDLINE and EMBASE databases. Using the data from the retrieved articles, we computed summary estimates of the associations of the four variants with T2DM risk. We also examined the studies for heterogeneity, as well as for bias of the publications. Results: A total of 113,025 T2DM patients and 199,997 controls from 38 articles were included in the meta-analysis. Overall, the pooled results indicated that GCK (rs1799884), GCKR (rs780094) and MTNR1B (rs10830963) were significantly associated with T2DM susceptibility (OR, 1.04; 95%CI, 1.01–1.08; OR, 1.08; 95%CI, 1.05–1.12 and OR, 1.05; 95%CI, 1.02–1.08, respectively). After stratification by ethnicity, significant associations for the GCK, MTNR1B and G6PC2 variants were detected only in Caucasians (OR, 1.09; 95%CI, 1.02–1.16; OR, 1.10; 95%CI, 1.08–1.13 and OR, 0.97; 95%CI, 0.95–0.99, respectively), but not in Asians (OR, 1.02, 95% CI 0.98–1.05; OR, 1.01; 95%CI, 0.98–1.04 and OR, 1.12; 95%CI, 0.91–1.32, respectively). Conclusions: Our meta-analyses demonstrated that GCKR rs780094 variant confers high cross-ethnicity risk for the development of T2DM, while significant associations between GCK, MTNR1B and G6PC2 variants and T2DM risk are limited to Caucasians.

Suggested Citation

  • Haoran Wang & Lei Liu & Jinzhao Zhao & Guanglin Cui & Chen Chen & Hu Ding & Dao Wen Wang, 2013. "Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0067665
    DOI: 10.1371/journal.pone.0067665
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    References listed on IDEAS

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    1. Qing Xia & Zi-Xian Chen & Yi-Chao Wang & Yu-Shui Ma & Feng Zhang & Wu Che & Da Fu & Xiao-Feng Wang, 2012. "Association between the Melatonin Receptor 1B Gene Polymorphism on the Risk of Type 2 Diabetes, Impaired Glucose Regulation: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    2. Claudia Ha Ting Tam & Janice Sin Ka Ho & Ying Wang & Heung Man Lee & Vincent Kwok Lim Lam & Soren Germer & Mitchell Martin & Wing Yee So & Ronald Ching Wan Ma & Juliana Chung Ngor Chan & Maggie Chor Y, 2010. "Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects," PLOS ONE, Public Library of Science, vol. 5(7), pages 1-8, July.
    3. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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