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Genetic Polymorphism of the Kinesin-Like Protein KIF1B Gene and the Risk of Hepatocellular Carcinoma

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  • Zhi-Chao Wang
  • Qiang Gao
  • Jie-Yi Shi
  • Liu-Xiao Yang
  • Jian Zhou
  • Xiao-Ying Wang
  • Ying-Hong Shi
  • Ai-Wu Ke
  • Guo-Ming Shi
  • Zhen-Bin Ding
  • Zhi Dai
  • Shuang-Jian Qiu
  • Jia Fan

Abstract

Background: Frequent deletions of the kinesin-like protein gene 1B (KIF1B) have been reported in neural tumors. Recently, a genome-wide association study revealed an association between polymorphisms in the KIF1B gene and the risk of hepatocellular carcinoma (HCC), and several case-control studies have further investigated this relationship. However, these studies have yielded controversial results. We therefore performed a meta-analysis to derive a more precise estimation of the association between the KIF1B gene polymorphisms and HCC risk. Methodology/Principal Finding: PubMed, EMBASE, the ISI Web of Science and the CNKI databases were systematically searched to identify relevant studies. A total of 5 studies containing 13 cohorts with 5,773 cases and 6,404 controls were included. Odds ratios (ORs) with corresponding 95% confidence intervals (CIs) were used to assess the strength of the associations. Subgroup analyses were conducted based on ethnicities, sample sizes and quality scores. Overall, the G allele at rs17401966 of the KIF1B gene was associated with a significantly decreased risk for HCC (OR = 0.81, 95%CI: 0.70–0.93; P = 0.003). Furthermore, subgroup analyses showed that the G allele at rs17401966 of the KIF1B gene significantly reduced the risk for HCC in Chinese cohorts (OR = 0.76, 95%CI: 0.64–0.90; P = 0.002), large-sample-size cohorts (OR = 0.80, 95%CI: 0.73–0.88, P

Suggested Citation

  • Zhi-Chao Wang & Qiang Gao & Jie-Yi Shi & Liu-Xiao Yang & Jian Zhou & Xiao-Ying Wang & Ying-Hong Shi & Ai-Wu Ke & Guo-Ming Shi & Zhen-Bin Ding & Zhi Dai & Shuang-Jian Qiu & Jia Fan, 2013. "Genetic Polymorphism of the Kinesin-Like Protein KIF1B Gene and the Risk of Hepatocellular Carcinoma," PLOS ONE, Public Library of Science, vol. 8(4), pages 1-6, April.
  • Handle: RePEc:plo:pone00:0062571
    DOI: 10.1371/journal.pone.0062571
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    References listed on IDEAS

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    1. Shengping Li & Ji Qian & Yuan Yang & Wanting Zhao & Juncheng Dai & Jin-Xin Bei & Jia Nee Foo & Paul J McLaren & Zhiqiang Li & Jingmin Yang & Feng Shen & Li Liu & Jiamei Yang & Shuhong Li & Shandong Pa, 2012. "GWAS Identifies Novel Susceptibility Loci on 6p21.32 and 21q21.3 for Hepatocellular Carcinoma in Chronic Hepatitis B Virus Carriers," PLOS Genetics, Public Library of Science, vol. 8(7), pages 1-8, July.
    2. Alessandro Liberati & Douglas G Altman & Jennifer Tetzlaff & Cynthia Mulrow & Peter C Gøtzsche & John P A Ioannidis & Mike Clarke & P J Devereaux & Jos Kleijnen & David Moher, 2009. "The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of Studies That Evaluate Health Care Interventions: Explanation and Elaboration," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-28, July.
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